Results 11 to 20 of about 4,157,307 (334)

Viral Evolution

Viral Pathogenesis, 2016
Viral infection is a highly dynamic process, which lead to constant evolutionary changes on both sides of the viral–host interface. The high mutation rates of viruses, coupled with short generation times and large population sizes, allow viruses to ...
A. Stern, R. Andino
semanticscholar   +2 more sources

INTERGENERATIONAL PHENOTYPIC MIXING IN VIRAL EVOLUTION [PDF]

Evolution, 2013
Viral particles (virions) are made of genomic material packaged with proteins, drawn from the pool of proteins in the parent cell. It is well known that when virion concentrations are high, cells can be coinfected with multiple viral strains that can complement each other. Viral genomes can then interact with proteins derived from different strains, in
C. Loverdo, J. Lloyd-Smith
semanticscholar   +3 more sources

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

bioRxiv, 2022
SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies.
Tyler N. Starr, Allison J. Greaney, William W. Hannon, Andrea N. Loes, Kevin Hauser, J. Dillen, E. Ferri, A. G. Farrell, Bernadeta Dadonaite, M. McCallum, Kenneth A. Matreyek, D. Corti, D. Veesler, G. Snell, J. Bloom   +14 more
semanticscholar   +1 more source

An increase in enterovirus D68 circulation and viral evolution during a period of increased influenza like illness, The Johns Hopkins Health System, USA, 2022.

Journal of Clinical Virology, 2023
BACKGROUND An increase in influenza like illness in children and adolescents at the Johns Hopkins Health system during summer 2022 was associated with increased positivity for enterovirus/ rhinovirus.
A. Fall, Lijie Han, O. Abdullah, J. Norton, R. Eldesouki, M. Forman, C. P. Morris, E. Klein, H. Mostafa   +8 more
semanticscholar   +1 more source

The biophysical landscape of viral evolution. [PDF]

Proc Natl Acad Sci U S A
Wilke CO.
europepmc   +3 more sources

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host

Nature Communications, 2022
Different scenarios explaining the emergence of novel variants of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported, including their evolution in scarcely monitored populations, in animals as alternative
S. Sonnleitner, M. Prelog, S. Sonnleitner, E. Hinterbichler, H. Halbfurter, D. B. Kopecky, G. Almanzar, Stephan Koblmüller, C. Sturmbauer, L. Feist, R. Horres, W. Posch, G. Walder   +12 more
semanticscholar   +1 more source

Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review

Clinical Infection in Practice, 2022
Background Most patients with SARS-CoV-2 are non-infectious within 2 weeks, though viral RNA may remain detectable for weeks. However there are reports of persistent SARS-CoV-2 infection, with viable virus and ongoing infectivity months after initial ...
D. Hettle, S. Hutchings, P. Muir, E. Moran   +3 more
semanticscholar   +1 more source

Viral Quasispecies Evolution [PDF]

Microbiology and Molecular Biology Reviews, 2012
SUMMARYEvolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics.
Domingo, Esteban, Sheldon, Julie, Perales, Celia   +2 more
openaire   +3 more sources

Intradermal needle-free injection prevents African Swine Fever transmission, while intramuscular needle injection does not

Scientific Reports, 2023
Shared needles are a possible iatrogenic and hematogenous inanimate vector of African Swine Fever virus (ASFV) in farm conditions. To evaluate that possible transmission, sixty, 4-week-old pigs were procured from an ASF free herd free. Upon arrival, pigs
Muhammad Salman, Hongyao Lin, Roypim Suntisukwattana, Parin Watcharavongtip, Patumporn Jermsutjarit, Angkana Tantituvanont, Dachrit Nilubol   +6 more
doaj   +1 more source

Immuno-epidemiology and the predictability of viral evolution

Science, 2022
Description Understanding viral evolution depends on a synthesis of evolutionary biology and immuno-epidemiology Despite much recent progress in modeling the epidemiology and evolution of acute viruses, a full quantitative synthesis of viral eco ...
C. Saad-Roy, C. Metcalf, B. Grenfell
semanticscholar   +1 more source