Paramyxovirus membrane fusion: Lessons from the F and HN atomic structures [PDF]
, 2006 Paramyxoviruses enter cells by fusion of their lipid envelope with the target cell plasma membrane. Fusion of the viral membrane with the plasma membrane allows entry of the viral genome into the cytoplasm.
Jardetzky, Theodore S. +2 more
core +1 more source
Influence of salt and viral protein charge distribution on encapsidation of single-stranded viral RNA molecules [PDF]
arXiv, 2008 We examine the limits on viral composition that are set by the electrostatic interactions effected by the charge on the viral proteins, the single-stranded viral RNA molecule and monovalent salt ions in the solution. Within the mean-field model of viral energetics we demonstrate the prime importance of the salt concentration for the assembly of a virus.
arxiv
Systematic Approach on Differences in Avian Viral Proteins Based on Carbon Composition [PDF]
arXiv, 2011 The distribution of amino acid along the protein sequences plays an imperative role in facilitating different biological functions. Currently, there is insufficient scientific data, which represents the arrangement of amino acid in the proteins based on atomic composition.
arxiv
Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]
, 2009 The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Ehrhardt, Anja +2 more
core +4 more sources
Viral entry mechanisms: the role of molecular simulation in unlocking a key step in viral infections
FEBS Open BioViral infections are a major global health concern, affecting millions of people each year. Viral entry is one of the crucial stages in the infection process, but its details remain elusive.
Mariana Valério +4 more
doaj +1 more source
Stochastic model of endosomal escape of Influenza virus [PDF]
arXiv, 2015 Influenza viruses enter a cell via endocytosis after binding to the surface. During the endosomal journey, acidification triggers a conformational change of the virus spike protein hemagglutinin (HA) that results in escape of the viral genome from the endosome to the cytoplasm.
arxiv
Mitochondrial dynamics and viral infections: A close nexus. [PDF]
, 2015 Viruses manipulate cellular machinery and functions to subvert intracellular environment conducive for viral proliferation. They strategically alter functions of the multitasking mitochondria to influence energy production, metabolism, survival, and ...
Khan, Mohsin +3 more
core +2 more sources
Assembly and budding of influenza virus. [PDF]
, 2004 Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata +2 more
core
Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]
, 2010 Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Dortmans, J.C.F.M. +3 more
core +2 more sources
Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins. [PDF]
Biochemistry, 2023 Landry SJ +6 more
europepmc +1 more source