Results 81 to 90 of about 220,573 (114)

Properties of a Viral Fusion Protein

1988
The mechanisms by which proteins mediate biological membrane fusion are not clearly understood. We have analyzed acid-induced changes in influenza hemagglutinin (HA), a viral membrane fusion factor, and correlated them with its acid-triggered fusion activity.
Robert W. Doms, Ari Helenius
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Fusion inhibition: Bioassay of a Type C viral protein

Virology, 1975
Abstract Based on the observation that concentrated RD-114 virus directly induces fusion in a Rous sarcoma virus-transformed human glioma cell line, KC, an RD-114 virus protein was identified which had the property of inhibiting this fusion. The protein was irreversibly denatured by 2-mercaptoethanol, reacted with neutralizing sera to RD-114 virus ...
K, Rand, J, Davis, R V, Gilden, S, Oroszlan, C, Long   +4 more
openaire   +2 more sources

Peripherin-2:  An Intracellular Analogy to Viral Fusion Proteins

Biochemistry, 2007
The C-terminus of the intracellular retinal rod outer segment disk protein peripherin-2 binds to membranes, adopts a helical conformation, and promotes membrane fusion, which suggests an analogy to the structure and function of viral envelope fusion proteins. Nuclear magnetic resonance (NMR) data and fluorescence data show that a 63-residue polypeptide
T C, Edrington, R, Lapointe, P L, Yeagle, C L, Gretzula, K, Boesze-Battaglia   +4 more
openaire   +2 more sources

Viral proteins in cell fusion.

The Tokai journal of experimental and clinical medicine, 1983
F (fusion) and HANA (hemagglutinin and neuraminidase) glycoproteins of HVJ (Sendai virus) were purified and characterized. The NH2-terminal hydrophobic region of the F1 (larger) subunit of F (fusion)-glycoprotein seems to be required for the hemolytic and cell fusion-inducing activity of the virus for the following reasons.
A, Asano, K, Asano
openaire   +1 more source

Pore Formation in Target Liposomes by Viral Fusion Proteins

2003
Publisher Summary This chapter introduces methodologies to characterize plasma-membrane and viral-membrane interactions in a model system using liposomes as target membranes. It focuses on hemagglutinin (HA), a trimeric integral membrane protein that protrudes from the viral membrane as a spike, with a long stem and a globular tip.
Pierre, Bonnafous, Toon, Stegmann
openaire   +2 more sources

Patch clamp studies of single cell-fusion events mediated by a viral fusion protein

Nature, 1989
To enter cells, viruses must fuse their envelope with a host cell membrane. Fusion is mediated by specific, membrane-spanning fusion proteins, of which the influenza virus haemagglutinins (HA) are the best characterized. Several HAs have been sequenced, and the crystal structure of the major part of one HA is known.
A E, Spruce, A, Iwata, J M, White, W, Almers   +3 more
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Peptide models for the membrane destabilizing actions of viral fusion proteins

Biopolymers, 1992
AbstractThe fusion of enveloped viruses to target membranes is promoted by certain viral fusion proteins. However, many other proteins and peptides stabilize bilayer membranes and inhibit membrane fusion. We have evaluated some characteristics of the interaction of peptides that are models of segments of measles and influenza fusion proteins with ...
R M, Epand, J J, Cheetham, R F, Epand, P L, Yeagle, C D, Richardson, A, Rockwell, W F, Degrado   +6 more
openaire   +2 more sources

Mechanism and energetics of lipid recognition by viral fusion proteins

2023
During viral infection, viral fusion proteins bind to the host cell membrane prior to catalyzing the fusion of the viral envelope with the host membrane. The atomic architectures of fusion proteins and their interactions with membrane receptors have been revealed by numerous structural studies, however, the interactions of fusion proteins with the host
Poojari, Chetan, Bommer, Tobias, Hub, Jochen   +2 more
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Targeting the Hendra Virus Fusion Protein Transmembrane Domain to Inhibit Viral Fusion

The FASEB Journal, 2017
Hendra Virus is a zoonotic virus in the family Paramyxoviridae. It is an enveloped, negative sense single stranded RNA virus that is highly pathogenic, but currently there is no approved antiviral therapeutic or vaccine. Further elucidation of the mechanisms that underlie viral entry into a cell will assist in presenting additional targets for ...
Chelsea Barrett, Stacy Webb, Rebecca Dutch   +2 more
openaire   +1 more source

Viral Fusion Protein TM-TM Interactions

2017
Enveloped viruses, such as HIV, influenza, and Ebola, utilize surface glycoproteins to bind and fuse with a target cell membrane. This fusion event is necessary for release of viral genomic material so the virus can ultimately reproduce and spread.
openaire   +1 more source