Results 81 to 90 of about 220,849 (250)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

Nature Communications
Viral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which involves dramatic transitions from their pre- to postfusion conformations.
Sonal V. Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S. McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B. Blomberg, Christopher P. Marshall, Mark A. Yondola   +13 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry

Journal of Biomedical Science, 2009
Background Envelope (E) glycoprotein E2 of the hepatitis C virus (HCV) mediates binding of the virus to target cell receptors. Nevertheless, the precise role of E1 in viral entry remains elusive.
Chuang Chin-Kai, Ai Li-Shuang, Huang Chia-Hsuan, Li Hsiao-Fen, Chen Steve SL   +4 more
doaj   +1 more source

Putative Fusion-Associated Small Transmembrane (FAST) Proteins Encoded by Viruses of Pistolviridae, Order Ghabrivirales, Identified from In Silico Analyses

Viruses
Fusion-associated small transmembrane (FAST) proteins are viral nonstructural proteins known to be encoded by specific members of the Spinareoviridae, specifically within the Aquareovirus and Orthoreovirus genera.
Racheal Amono, Turhan Markussen, Øystein Evensen, Aase B. Mikalsen   +3 more
doaj   +1 more source

Receptor-Activated Binding of Viral Fusion Proteins to Target Membranes

, 2003
This chapter describes three assays to monitor receptor-induced association of the envelope glycoprotein (EnvA) of avian sarcoma/leukosis virus (ASLV) with target bilayers: (1) the original assay for monitoring binding of the EnvA ectodomain (EnvA-PI) to target membranes (liposomes), (2) a modified and miniaturized EnvA-PI-liposome binding assay, and ...
Earp, Laurie J, Hernandez, Lorraine D, Delos, Sue E, White, Judith M   +3 more
openaire   +2 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Zyxin restricts viral fusion and entry across multiple virus families

Journal of Virology
The entry of enveloped viruses into host cells requires fusion of the viral envelope with a host cell membrane. The composition and dynamics of cellular membranes are impacted by the underlying cytoskeleton.
Qing Fan, Jenai Quan, Gregory A. Smith, Richard Longnecker   +3 more
doaj   +1 more source

IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections

Frontiers in Microbiology, 2019
Interferon-induced transmembrane proteins (IFITMs) are a family of small proteins that localize in the plasma and endolysosomal membranes. IFITMs not only inhibit viral entry into host cells by interrupting the membrane fusion between viral envelope and ...
Xuesen Zhao, Xuesen Zhao, Jiarui Li, Jiarui Li, Cheryl A. Winkler, Ping An, Ju-Tao Guo   +6 more
doaj   +1 more source