Results 81 to 90 of about 334,138 (333)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]

, 2015
Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...

core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Rainbow Kaposi's Sarcoma-Associated Herpesvirus Revealed Heterogenic Replication with Dynamic Gene Expression. [PDF]

, 2020
Molecular mechanisms of Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation have been studied primarily by measuring the total or average activity of an infected cell population, which often consists of a mixture of both nonresponding and ...
Campbell, Mel, Chuang, Frank, Guevara-Plunkett, Sara, Izumiya, Chie, Izumiya, Yoshihiro, Kumar, Ashish, Luxardi, Guillaume, Lyu, Yuanzhi, Nakajima, Ken-Ichi, Soulika, Athena, Wang, Kang-Hsin   +10 more
core  

Self-organizing & stochastic behaviors during the regeneration of hair stem cells [PDF]

, 2011
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative ...
Andl, T, Baker, RE, Chen, CC, Chuong, CM, de la Cruz, D, Fare, C, Maini, Philip, Millar, SE, Plikus, MV, Widelitz, R   +9 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Design of a bifunctional pan-sarbecovirus entry inhibitor targeting the cell receptor and viral fusion protein [PDF]

, 2023
Hongliang Jin, Lin Cheng, Yani Gong, Yuanmei Zhu, Huihui Chong, Zheng Zhang, Yuxian He   +6 more
openalex   +1 more source

Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism

Journal of General Virology, 1995
Introduction. Entry of enveloped viruses into host cells requires binding of the virus to one or more receptors present at the host cell surface followed by fusion of the viral envelope with a cellular membrane. After binding, viruses such as paramyxoviruses, retroviruses and herpesviruses are thought to fuse directly with the plasma membrane.
Y, Gaudin, R W, Ruigrok, J, Brunner
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism.

PLoS Pathogens
B cells play a crucial role in humoral immunity, acting as sentinels against viral infections by using their B cell receptors (BCRs) to recognize viral proteins.
Rene Larios, Md Belal Hossain, Rebecca Brown, Arjit Vijey Jeyachandran, Angel Elma Abu, Anne Kathrin Zaiss, Christina M Ramirez, Masakazu Kamata, Steve Cole, Ting-Ting Wu, Kenneth Dorshkind, Vaithilingaraja Arumugaswami, Kouki Morizono   +12 more
doaj   +1 more source