Results 71 to 80 of about 225,504 (153)
, 2015 Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular
Harrison, Stephen C.
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Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
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Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro. [PDF]
mSphere, 2018 Webb SR, Smith SE, Fried MG, Dutch RE.
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Inhibition of Viral Fusion by Interferon-Induced Transmembrane Proteins [PDF]
Biophysical Journal, 2021 Xiangyang Guo +4 more
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De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. [PDF]
J Med Chem, 2018 Wang C +12 more
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Macrocyclic peptide inhibitors of viral fusion proteins
Pandemic outbreaks of viruses present a significant global challenge, necessitating continuous updates to vaccines and exploration of new antiviral drugs. This thesis explores a strategy targeting the coat glycoproteins of two pandemic viruses to discover new broadly active antiviral drugs.
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, 2014 In nature, proteins with weak binding affinity often use a multivalency approach to enhance protein affinity via an avidity effect. Interested in this multivalency approach, we have isolated a carbohydrate binding module (CBM) that recognises sialic ...
Alias, Nadiawati
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
, 2014 Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
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, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
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Cell-based membrane fusion assays with viral fusion proteins for identification of entry inhibitors
Translational and Regulatory Sciences, 2021 YAMAMOTO, Mizuki, GOHDA, Jin
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