Results 71 to 80 of about 225,504 (153)

Viral membrane fusion

open access: yes, 2015
Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular
Harrison, Stephen C.
core   +1 more source

Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins

open access: yes
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
core   +1 more source

Inhibition of Viral Fusion by Interferon-Induced Transmembrane Proteins [PDF]

open access: yesBiophysical Journal, 2021
Xiangyang Guo   +4 more
openaire   +1 more source

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. [PDF]

open access: yesJ Med Chem, 2018
Wang C   +12 more
europepmc   +1 more source

Macrocyclic peptide inhibitors of viral fusion proteins

open access: yes
Pandemic outbreaks of viruses present a significant global challenge, necessitating continuous updates to vaccines and exploration of new antiviral drugs. This thesis explores a strategy targeting the coat glycoproteins of two pandemic viruses to discover new broadly active antiviral drugs.
openaire   +2 more sources

Multivalent sialic acid binding proteins as novel therapeutics for influenza and parainfluenza infection

open access: yes, 2014
In nature, proteins with weak binding affinity often use a multivalency approach to enhance protein affinity via an avidity effect. Interested in this multivalency approach, we have isolated a carbohydrate binding module (CBM) that recognises sialic ...
Alias, Nadiawati
core  

Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness

open access: yes, 2014
Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core  

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections

open access: yes, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core  

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