Results 141 to 150 of about 319,921 (262)

Macrocyclic peptide inhibitors of viral fusion proteins

Pandemic outbreaks of viruses present a significant global challenge, necessitating continuous updates to vaccines and exploration of new antiviral drugs. This thesis explores a strategy targeting the coat glycoproteins of two pandemic viruses to discover new broadly active antiviral drugs.
openaire   +2 more sources

Predicting sub-population specific viral evolution [PDF]

arXiv
Forecasting the change in the distribution of viral variants is crucial for therapeutic design and disease surveillance. This task poses significant modeling challenges due to the sharp differences in virus distributions across sub-populations (e.g., countries) and their dynamic interactions.
arxiv  

Initial size and dynamics of viral fusion pores are a function of the fusion protein mediating membrane fusion [PDF]

, 2008
Ilya Plonsky, David H. Kingsley, Afshin Rashtian, Paul S. Blank, Joshua Zimmerberg   +4 more
openalex   +1 more source

Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication

Cell Reports, 2018
Summary: Picornaviruses have evolved to hijack host cellular machinery, including the autophagic pathway. However, the mechanisms remain largely unclear.
Yasir Mohamud, Junyan Shi, Junyan Qu, Tak Poon, Yuan Chao Xue, Haoyu Deng, Jingchun Zhang, Honglin Luo   +7 more
doaj  

Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein (γ penetrene) [PDF]

, 2009
Courtney E. Garry, Robert F. Garry
openalex   +1 more source

Pseudotyping exosomes for enhanced protein delivery in mammalian cells. [PDF]

, 2017
Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins ...
Li, Lingxuan, Losacco, Joseph, Lu, Biao, Marriott, Gerard, Meyer, Conary, Stickney, Zachary   +5 more
core  

RSV fusion (F) protein DNA vaccine provides partial protection against viral infection [PDF]

, 2009
Hongzhuan Wu, Vida A. Dennis, Shreekumar Pillai, Shree R. Singh   +3 more
openalex   +1 more source

Interaction of Sendai virus proteins with the cytoplasmic surface of erythrocyte membranes following viral envelope fusion.

, 1981
Steven E. Caldwell, Douglas S. Lyles
openalex   +1 more source

Negative Potentials Across Biological Membranes Promote Fusion by Class II and Class III Viral Proteins [PDF]

, 2010
Ruben M. Markosyan, Fredric S. Cohen
openalex   +1 more source

Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein

, 1998
Sophie Snitkovsky, John A. T. Young
openalex   +1 more source