Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex [PDF]
Cell Reports, 2021 SUMMARY The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity in the body by ...
Maya M L Poon +2 more
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Understanding T cell aging to improve anti-viral immunity. [PDF]
Curr Opin Virol, 2021 T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility to ...
Zhang H +3 more
europepmc +2 more sources
Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease. [PDF]
Nat Cardiovasc Res, 2022 Pre-existent cardiovascular disease is a risk factor for weak anti-viral immunity, but underlying mechanisms remain undefined. Here we report that patients with coronary artery disease (CAD) have macrophages (Mϕ) that actively suppress the induction of ...
Zhao TV +8 more
europepmc +2 more sources
The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity. [PDF]
Front Immunol, 2021 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial ...
Torti MF +3 more
europepmc +2 more sources
HLA Class I Molecules as Immune Checkpoints for NK Cell Alloreactivity and Anti-Viral Immunity in Kidney Transplantation. [PDF]
Front Immunol, 2021 Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines upon activation.
Duygu B +4 more
europepmc +2 more sources
Tissue resident memory T cells and viral immunity. [PDF]
Curr Opin Virol, 2017 Tissue resident memory T cells (TRM) constitute a recently identified T cell lineage that is responsible for frontline defense against viral infections. In contrast to central and effector memory T cells, which constitutively recirculate between tissues ...
Rosato PC, Beura LK, Masopust D.
europepmc +2 more sources
APOBEC3 Proteins in Viral Immunity. [PDF]
J Immunol, 2015 Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses ...
Stavrou S, Ross SR.
europepmc +2 more sources
Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity
, 2020 Main protease and papain-like protease (PLpro) are essential coronaviral enzymes required for polypeptide processing during viral maturation. PLpro additionally cleaves proteinous post-translational modifications from host proteins to evade anti-viral ...
Shin D +19 more
europepmc +2 more sources
Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity
Viruses, 2017 Recognition of viral glycans by pattern recognition receptors (PRRs) in innate immunity contributes to antiviral immune responses. C-type lectin receptors (CLRs) are PRRs capable of sensing glycans present in viral pathogens to activate antiviral immune ...
João T Monteiro, Bernd Lepenies
exaly +2 more sources
Nature Reviews Molecular Cell Biology, 2022 Sara Lopez-Gomollon, David C Baulcombe
exaly +2 more sources