Results 21 to 30 of about 3,154,220 (254)

Viral miRNAs and immune evasion [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
Viral miRNAs, ~22nt RNA molecules which post-transcriptionally regulate gene expression, are emerging as important tools in immune evasion. Viral infection is a complex process that requires immune evasion in order to establish persistent life-long infection of the host.
Department of Molecular Genetics and Microbiology, University of Florida Mowry Road, Gainesville, FL 32610, USA ( host institution ), Boss, Isaac W. ( author ), Renne, Rolf ( author )   +2 more
openaire   +3 more sources

Viral pathogenesis and immune control [PDF]

Journal of Neurovirology, 2002
Understanding viral structure-function relationships, interactions with host cells or the host’s immune system are crucial for understanding the pathomechanisms of viral infections, modulation of immune responses, and the development of effective and preventative and therapeutic measures.
Schneider-Schaulies, Sibylle, Rima, Bertus K., Hünig, Thomas   +2 more
openaire   +2 more sources

Lipid droplets and lipid mediators in viral infection and immunity

FEMS Microbiology Reviews, 2021
Lipid droplets (LDs) contribute to key pathways important for the physiology and pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids, protein sequestration, removal of toxic lipids and cellular communication ...
E. A. Monson, Alice M. Trenerry, Jay L Laws, J. Mackenzie, K. Helbig   +4 more
semanticscholar   +1 more source

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Nature, 2020
The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread1,2.
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, D. Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, M. Widera, A. Mehdipour, G. Tascher, P. Geurink, A. Wilhelm, Gerbrand J. van der Heden van Noort, H. Ovaa, S. Müller, K. Knobeloch, K. Rajalingam, B. Schulman, J. Cinatl, G. Hummer, S. Ciesek, I. Dikič   +21 more
semanticscholar   +1 more source

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series

EBioMedicine, 2021
Background There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses ...
Thao T. Truong, A. Ryutov, U. Pandey, R. Yee, Lior Goldberg, D. Bhojwani, P. Aguayo-Hiraldo, B. Pinsky, A. Pekosz, Lishuang Shen, S. Boyd, O. Wirz, K. Röltgen, M. Bootwalla, D. Maglinte, D. Ostrow, D. Ruble, Jennifer H. Han, J. Biegel, Maggie Li, ChunHong Huang, M. Sahoo, P. Pannaraj, M. O'gorman, A. Judkins, Xiaowu Gai, J. Dien Bard   +26 more
semanticscholar   +1 more source

ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

bioRxiv, 2018
Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked to autoimmunity and cancer, but functions in adaptive immunity are less ...
M. J. Moore, N. Blachere, J. Fak, Christopher Y. Park, K. Sawicka, S. Parveen, Ilana Zucker-Scharff, Bruno Moltedo, A. Rudensky, R. Darnell   +9 more
semanticscholar   +1 more source

Immune Checkpoints in Viral Infections [PDF]

Viruses, 2020
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism.
Huiming Cai, Ge Liu, Jianfeng Zhong, Kai Zheng, Haitao Xiao, Chenyang Li, Xun Song, Ying Li, Chenshu Xu, Haiqiang Wu, Zhendan He, Qinchang Zhu   +11 more
openaire   +3 more sources

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion [PDF]

Frontiers in Immunology, 2020
The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the course and severity of infection.
Vivian Lei, Vivian Lei, Amy J. Petty, Amber R. Atwater, Sarah A. Wolfe, Amanda S. MacLeod, Amanda S. MacLeod, Amanda S. MacLeod, Amanda S. MacLeod   +8 more
openaire   +3 more sources

Enhancing immunity in viral infections, with special emphasis on COVID-19: A review

Diabetes & metabolic syndrome, 2020
Background and aims Balanced nutrition which can help in maintaining immunity is essential for prevention and management of viral infections. While data regarding nutrition in coronavirus infection (COVID-19) are not available, in this review, we aimed ...
R. Jayawardena, P. Sooriyaarachchi, M. Chourdakis, C. Jeewandara, P. Ranasinghe   +4 more
semanticscholar   +1 more source

An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans

mBio, 2017
Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of the JAK kinases to induce ...
M. Tanguy, Louise Véron, Przemysław A. Stempor, J. Ahringer, P. Sarkies, E. Miska   +5 more
semanticscholar   +1 more source