Results 31 to 40 of about 623,045 (205)

Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection

Acta Neuropathologica Communications, 2023
As the resident parenchymal myeloid population in the central nervous system (CNS), microglia are strategically positioned to respond to neurotropic virus invasion and have been implicated in promoting both disease resolution and progression in the acute
Alanna G. Spiteri, Claire L. Wishart, Duan Ni, Barney Viengkhou, Laurence Macia, Markus J. Hofer, Nicholas J. C. King   +6 more
doaj   +1 more source

APOBEC3 Proteins in Viral Immunity. [PDF]

J Immunol, 2015
Abstract Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Stavrou S, Ross SR.
europepmc   +4 more sources

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Translating viral vaccines into immunity

Science, 2021
How adenoviral vaccines orchestrate adaptive immunity from innate responses is ...
Juno, Jennifer A., OConnor, Shelby L.
openaire   +2 more sources

Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine

BMC Infectious Diseases, 2023
Background The four co-circulating and immunologically interactive dengue virus serotypes (DENV1-4) pose a unique challenge to vaccine design because sub-protective immunity can increase the risk of severe dengue disease.
Camila D. Odio, Kelsey E. Lowman, Melissa Law, Rosemary A. Aogo, Sally Hunsberger, Brad J. Wood, Michael Kassin, Elliot Levy, Viviane Callier, Saba Firdous, Chloe M. Hasund, Charlie Voirin, Robbie Kattappuram, Christina Yek, Jessica Manning, Anna Durbin, Stephen S. Whitehead, Leah C. Katzelnick   +17 more
doaj   +1 more source

Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity

Frontiers in Immunology, 2022
Growth differentiation factor 15 (GDF-15) is a transforming growth factor (TGF)-β superfamily cytokine that plays a central role in metabolism regulation.
Darakhshan Sohail Ahmed, Darakhshan Sohail Ahmed, Stéphane Isnard, Stéphane Isnard, Stéphane Isnard, Carolina Berini, Carolina Berini, Carolina Berini, John Lin, John Lin, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, Léna Royston, Léna Royston, Léna Royston, Léna Royston   +16 more
doaj   +1 more source

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]

, 2019
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid, Couck, Liesbeth, Favoreel, Herman, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +7 more
core   +1 more source

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]

, 2016
Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris, Brown, James R., Charman, Matthew, Conn, Kristen L., Grant, Kyle, McFarlane, Steven, Tong, Lily, Wasson, Peter   +7 more
core   +1 more source

Modeling microevolution in a changing environment: The evolving quasispecies and the Diluted Champion Process

, 2011
Several pathogens use evolvability as a survival strategy against acquired immunity of the host. Despite their high variability in time, some of them exhibit quite low variability within the population at any given time, a somehow paradoxical behavior ...
Davide Fichera, Derrida B, Fisher R A, Fisher R A, Franz S, Ginestra Bianconi, Luca Peliti, Park S C, Shankarappa R, Silvio Franz, Tria F, Webster R G, Wright S, Wright S   +13 more
core   +3 more sources