Results 211 to 220 of about 2,533,210 (238)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Photo Quiz: Persistent papules in an immunocompromised child. [PDF]

J Clin Microbiol
Broadfoot BG, Mallampati S, Jackson SM, Boyanton BL.   +3 more
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Prevalence and Predictors of Gastrointestinal Infections Among Patients With Acute Severe Ulcerative Colitis and Those in Remission: A Cross-Sectional Study. [PDF]

Cureus
Bassi N, Ghoshal UC, Dixit VK, Ghoshal U, Yadav D, Banerjee T, Tiwari AK, Kumar V, Malakar S, Mahajan M, Shah AS, Mittal I, Parihar SP.   +12 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Atypical felid alphaherpesvirus 1 dermatitis in a cat. [PDF]

J Vet Diagn Invest
Sebastian Pineda DA, Maboni G, Garcia G, Baker C, Bacon L, Rissi DR.   +5 more
europepmc   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Human respiratory syncytial virus regulates the expression of interferon-stimulated genes through modulation of fibrillarin. [PDF]

Front Cell Infect Microbiol
Ulloa-Aguilar JM, Cruz-Holguin VJ, Benítez-Zeferino YR, Guzmán-Bautista ER, García-Cordero J, De Jesús-González LA, Vázquez-Martínez JA, Vázquez-Martínez ER, Herrera-Moro Huitron L, Mosqueda-Gracida A, Viveros-Rogel M, Vergara-Mendoza M, Miranda-Labra RU, León-Juárez M.   +13 more
europepmc   +1 more source

Relationship between promyelocytic leukemia protein nuclear bodies and TAR DNA-binding protein-43 aggregation in spinal anterior horn cells in sporadic amyotrophic lateral sclerosis. [PDF]

J Neuropathol Exp Neurol
Mori F, Kon T, Itazawa R, Akatsu A, Miki Y, Arai A, Kurotaki H, Tomiyama M, Wakabayashi K.   +8 more
europepmc   +1 more source

Rational design and high-yield expression of SARS-CoV-2 nucleocapsid antigen for a sensitive and specific in-house ELISA. [PDF]

BMC Biotechnol
Tazarghi A, Behrouzikhah M, Abbasi H, Ebrahimi M, Tabarraei A, Yamchi A, Razavi Nikoo H.   +6 more
europepmc   +1 more source