New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections [PDF]
Cells, 2021 Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication.
Olga Dolnik, Nadine Biedenkopf
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Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies [PDF]
PLoS ONE, 2015 Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Qin Fang, Fuxian Zhang, Liming Yan
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Aquareovirus NS80 Recruits Viral Proteins to Its Inclusions, and Its C-Terminal Domain Is the Primary Driving Force for Viral Inclusion Formation [PDF]
PLoS ONE, 2013 Cytoplasmic inclusion bodies formed in reovirus-infected cells are the sites of viral replication and assembly. Previous studies have suggested that the NS80 protein of aquareovirus may be involved in the formation of viral inclusion bodies.
Qin Fang
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Cells, 2020 Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors.
Sven Reiche +2 more
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Molluscum Contagiosum Complicated With an Epidermal Cyst: A Case Report [PDF]
Clinical Case ReportsMolluscum contagiosum (MC) is a viral infection that primarily affects pediatric patients, sexually active young adults, and immunocompromised individuals of all ages.
Ruixian Niu +6 more
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Liquid-liquid phase separation mediated immune evasion of respiratory syncytial virus against oligoadenylate synthetase-RNase L pathway. [PDF]
PLoS PathogensRespiratory syncytial virus (RSV) infection is the major cause of severe respiratory illnesses in infants and older adults. RSV forms phase-separated biomolecular condensates called inclusion bodies (IBs), which serve as hubs for viral replication ...
Woo Yeon Hwang +3 more
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Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs [PDF]
PLoS Pathogens, 2018 Viral invasion triggers the activation of the host antiviral response. Besides the innate immune response, stress granules (SGs) also act as an additional defense response to combat viral replication. However, many viruses have evolved various strategies
Mingzhou Chen, Xiaodan Yang
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Involvement of L polymerase and heat shock proteins in the biogenesis of viral circular RNAs derived from respiratory syncytial virus [PDF]
mBioCircular RNAs (circRNAs) are new members of noncoding RNAs that have gained increased attention, and reports on viral circRNAs and their functions continue to emerge in recent years.
Mingzhen Lin +11 more
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Frontiers in ImmunologySimilar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Ming Xian Chang
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Phytopathology ResearchMixed viral infections occur commonly in field plants. Such co-infections can lead to elevated titers of one or both viruses, potentially exacerbating symptom severity.
Jiejun Peng, , Peng Jiejun
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