New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections [PDF]
Cells, 2021 Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication.
Olga Dolnik +2 more
doaj +6 more sources
Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]
PLoS ONE, 2015 Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan +6 more
doaj +7 more sources
Aquareovirus NS80 recruits viral proteins to its inclusions, and its C-terminal domain is the primary driving force for viral inclusion formation. [PDF]
PLoS ONE, 2013 Cytoplasmic inclusion bodies formed in reovirus-infected cells are the sites of viral replication and assembly. Previous studies have suggested that the NS80 protein of aquareovirus may be involved in the formation of viral inclusion bodies.
Ling Shao +4 more
doaj +4 more sources
The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression [PDF]
Cells, 2020 Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors.
Lisa Wendt +6 more
doaj +4 more sources
Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. [PDF]
PLoS Pathogens, 2018 Viral invasion triggers the activation of the host antiviral response. Besides the innate immune response, stress granules (SGs) also act as an additional defense response to combat viral replication. However, many viruses have evolved various strategies
Zhulong Hu +5 more
doaj +4 more sources
Morphogenesis and functional organization of viral inclusion bodies
Cell Insight, 2023 Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, and ending with
Zhifei Li +4 more
doaj +3 more sources
PLoS BiologyProtein lysine methyltransferases (PKMTs) methylate histone and non-histone proteins to regulate biological outcomes such as development and disease including viral infection. While PKMTs have been extensively studied for modulating the antiviral responses via host gene regulation, their role in methylation of proteins encoded by viruses and its impact
Nishi Raj Sharma, Shravanti Rampalli
exaly +5 more sources
Unravelling the structure of viral replication complexes at super-resolution [PDF]
Frontiers in Plant Science, 2013 During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed ‘X bodies’, as their function was not immediately ...
Olga eLinnik +4 more
doaj +2 more sources
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
eLife, 2023 Viral inclusion bodies (IBs) commonly form during the replication of Ebola virus (EBOV) in infected cells, but their role in viral immune evasion has rarely been explored.
Lin Zhu +12 more
doaj +3 more sources
Nature Communications, 2017 Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval +9 more
doaj +2 more sources