Results 31 to 40 of about 82,636 (249)

Modulation of plant autophagy during pathogen attack [PDF]

, 2017
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O., Duggan, Cian, Leary, Alexandre Y, Pandey, Pooja, Salguero Linares, Jose, Sanguankiattichai, Nattapong, Savage, Zachary D, Segretin, Maria Eugenia, Tumtas, Yasin, Yow, Rui Jin   +9 more
core   +1 more source

Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus

Nature Communications, 2023
Human metapneumovirus (HMPV) is a major cause of respiratory illness in young children. The HMPV polymerase (L) binds an obligate cofactor, the phosphoprotein (P).
Jack D. Whitehead, Hortense Decool, Cédric Leyrat, Loic Carrique, Jenna Fix, Jean-François Eléouët, Marie Galloux, Max Renner   +7 more
doaj   +1 more source

Formation and Function of Liquid-Like Viral Factories in Negative-Sense Single-Stranded RNA Virus Infections

Viruses, 2021
Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to organize intracellular membrane-less structures. Studies with non-segmented negative-sense (NNS) RNA viruses have uncovered a key role of LLPS in the formation of viral ...
Justin M. Su, Maxwell Z. Wilson, Charles E. Samuel, Dzwokai Ma   +3 more
doaj   +1 more source

Vector competence of Aedes vexans (Meigen), Culex poicilipes (Theobald) and Cx. quinquefasciatus Say from Senegal for West and East African lineages of Rift Valley fever virus [PDF]

, 2016
Background Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is a mosquito–borne, zoonotic pathogen. In Senegal, RVFV was first isolated in 1974 from Aedes dalzieli (Theobald) and thereafter from Ae. fowleri (de Charmoy), Ae. ochraceus Theobald,
Alioune, Gaye, Bob Ndeye, Sakha, Cheikh, Talla, Dia, Ibrahima, Diagne, Cheikh Tidiane, Diallo, Diawo, Diallo, Mawlouth, Gamou, Fall, Kohl, Alain, Ndiaye, El Hadji, Sall, Amadou Alpha, Yamar, B.A.   +11 more
core   +1 more source

Evasion of Antiviral Immunity through Sequestering of TBK1/IKKε/IRF3 into Viral Inclusion Bodies [PDF]

Journal of Virology, 2014
ABSTRACT Cells are equipped with pattern recognition receptors (PRRs) such as the Toll-like and RIG-I-like receptors that mount innate defenses against viruses. However, viruses have evolved multiple strategies to evade or thwart host antiviral responses.
Xiaodong, Wu, Xian, Qi, Bingqian, Qu, Zerui, Zhang, Mifang, Liang, Chuan, Li, Carol J, Cardona, Dexin, Li, Zheng, Xing   +8 more
openaire   +2 more sources

Folding and Oligomerization of the gp2b/gp3/gp4 Spike Proteins of Equine Arteritis Virus in Vitro

Viruses, 2012
Equine arteritis virus (EAV) is a small, positive-stranded RNA virus. The glycoproteins gp2b, gp3 and gp4 form a heterotrimer in the viral envelope, which is required for cell entry of EAV.
Aleksander Kabatek, Michael Veit
doaj   +1 more source

Innate immune basis for rift valley fever susceptibility in mouse models [PDF]

, 2017
Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the
Bruhns, Pierre, Flamand, Marie, Godon, Ophélie, Jouvion, Grégory, Lathan, Rashida, Malissen, Marie, Panthier, Jean-Jacques, Simon-Chazottes, Dominique   +7 more
core   +3 more sources

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.

PLoS Pathogens, 2018
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated.
Charles-Adrien Richard, Vincent Rincheval, Safa Lassoued, Jenna Fix, Christophe Cardone, Camille Esneau, Sergei Nekhai, Marie Galloux, Marie-Anne Rameix-Welti, Christina Sizun, Jean-François Eléouët   +10 more
doaj   +1 more source

Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics

Frontiers in Immunology, 2018
In the search for an eminently practical strategy to develop immunostimulants and vaccines for farmed fish, we have devised recombinant viral antigens presented as “nanopellets” (NPs).
Rosemary Thwaite, Jie Ji, Débora Torrealba, Julio Coll, Manel Sabés, Antonio Villaverde, Antonio Villaverde, Antonio Villaverde, Nerea Roher   +8 more
doaj   +1 more source

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV [PDF]

, 2015
Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large quantities at a cost affordable in HIV‐
Arcalis, E, Capell, T, Christou, P, Evans, A, Medina, V, O'Keefe, BR, Ramessar, K, Shattock, RJ, Stöger, E, Vamvaka, E   +9 more
core   +2 more sources