New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections [PDF]
Cells, 2021 Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication.
Olga Dolnik +2 more
doaj +7 more sources
Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]
PLoS ONE, 2015 Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan +6 more
doaj +7 more sources
Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication [PDF]
iScienceSummary: Viral inclusion bodies (VIBs) are subcellular structures required for efficient viral replication. How type II grass carp reovirus (GCRV-II), the mainly prevalent strain, forms VIBs is unknown.
Chu Zhang +4 more
doaj +6 more sources
Morphogenesis and functional organization of viral inclusion bodies [PDF]
Cell Insight, 2023 Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, and ending with
Zhifei Li +4 more
doaj +4 more sources
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity [PDF]
eLife, 2023 Viral inclusion bodies (IBs) commonly form during the replication of Ebola virus (EBOV) in infected cells, but their role in viral immune evasion has rarely been explored.
Lin Zhu +12 more
doaj +4 more sources
Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus [PDF]
Frontiers in Immunology, 2022 Grass carp reovirus (GCRV) is the most pathogenic double-stranded (ds) RNA virus among the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host factors to generate its infectious compartments beneficial for viral replication and ...
Jie Zhang +7 more
doaj +4 more sources
Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication [PDF]
Frontiers in ImmunologySimilar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li +8 more
doaj +4 more sources
Cytomegalovirus-associated esophageal ulcer in an immunocompetent infant: When should ganciclovir be administered? [PDF]
Korean Journal of Pediatrics, 2012 Cytomegalovirus (CMV)-associated esophageal ulcer is rare in immunocompetent infants. The presence of inclusion bodies and immunohistochemical staining for CMV in biopsy specimens obtained during esophagogastroduodenoscopy (EGD) indicate that such ulcers
Hyo-Jeong Jang +2 more
doaj +3 more sources
Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies. [PDF]
J Virol, 2014 ABSTRACT Cells are equipped with pattern recognition receptors (PRRs) such as the Toll-like and RIG-I-like receptors that mount innate defenses against viruses. However, viruses have evolved multiple strategies to evade or thwart host antiviral responses.
Wu X +8 more
europepmc +4 more sources
Cells, 2020 Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors.
Lisa Wendt +6 more
doaj +3 more sources