Unravelling the structure of viral replication complexes at super-resolution
Frontiers in Plant Science, 2013 During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed ‘X bodies’, as their function was not immediately ...
Olga eLinnik +4 more
doaj +1 more source
Viruses, 2020 Members of the Reoviridae family assemble virus factories within the cytoplasm of infected cells to replicate and assemble virus particles. Bluetongue virus (BTV) forms virus inclusion bodies (VIBs) that are aggregates of viral RNA, certain viral ...
Bjorn-Patrick Mohl +4 more
doaj +1 more source
Formation of large viroplasms and virulence of Cauliflower mosaic virus in turnip plants depend on the N-terminal EKI sequence of viral protein TAV. [PDF]
PLoS ONE, 2017 Cauliflower mosaic virus (CaMV) TAV protein (TransActivator/Viroplasmin) plays a pivotal role during the infection cycle since it activates translation reinitiation of viral polycistronic RNAs and suppresses RNA silencing.
Angèle Geldreich +8 more
doaj +1 more source
Advancing the pathologic phenotype of giant axonal neuropathy: early involvement of the ocular lens
Orphanet Journal of Rare Diseases, 2019 Giant axonal neuropathy (GAN; ORPHA: 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of intermediate filaments (IFs).
Diane Armao +5 more
doaj +1 more source
Nature Communications, 2017 Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval +9 more
doaj +1 more source
CRYSTALLINE INTRANUCLEAR INCLUSIONS IN THE RENAL TUBULAR EPITHELIUM OF DOGS [PDF]
Assiut Veterinary Medical Journal, 1987 Intranuclear inclusion bodies with characteristic shape were found in renal tubuler epithelium of dogs. These inclusions were found in 20 out of 50 animals postmortally examined in faculty of Vet. Med. Assiut University.
M.K. IBRAHIM, A.Z. MAHMOUD, A. NAFADY
doaj +1 more source
Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells. [PDF]
PLoS ONE, 2016 OBJECTIVE:PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs).
Ilker Kudret Sariyer +3 more
doaj +1 more source
Human Respiratory Syncytial Virus Infection in a Human T Cell Line Is Hampered at Multiple Steps
Viruses, 2021 Human respiratory syncytial virus (HRSV) is the most frequent cause of severe respiratory disease in children. The main targets of HRSV infection are epithelial cells of the respiratory tract, and the great majority of the studies regarding HRSV ...
Ricardo de Souza Cardoso +10 more
doaj +1 more source
Human Cytomegalovirus. Studies on the Mechanism of Viral Gytopathology and Inclusion Body Formation.
Experimental Biology and Medicine, 1967 SummaryWhen cultured human fetal fi-broblasts were infected by human cytomegalo-virus, virus-induced morphologic changes consisting of cytopathology, intracytoplasmic and intranuclear inclusion bodies developed during a 72-hour period. Thus, in this system, virus-induced cell changes followed closely upon viral multiplication.
R M, McAllister +2 more
openaire +2 more sources
RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.
PLoS Pathogens, 2018 Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated.
Charles-Adrien Richard +10 more
doaj +1 more source