Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells. [PDF]
PLoS ONE, 2016 OBJECTIVE:PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs).
Ilker Kudret Sariyer +3 more
doaj +1 more source
Inclusion Bodies in Ionic Liquids [PDF]
, 2023 The pivotal role of proteins in pharmaceuticals is challenged by stability issues, making the study of inclusion bodies—a source of insoluble protein aggregates—increasingly relevant.
Spadiut, Oliver +3 more
core +2 more sources
Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles [PDF]
, 2019 Nonsegmented negative-strand RNA viruses, including measles virus (MeV), a member of the Paramyxoviridae family, are assumed to replicate in cytoplasmic inclusion bodies.
Samuel, Charles E +3 more
core +1 more source
Human Respiratory Syncytial Virus Infection in a Human T Cell Line Is Hampered at Multiple Steps
Viruses, 2021 Human respiratory syncytial virus (HRSV) is the most frequent cause of severe respiratory disease in children. The main targets of HRSV infection are epithelial cells of the respiratory tract, and the great majority of the studies regarding HRSV ...
Ricardo de Souza Cardoso +10 more
doaj +1 more source
RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.
PLoS Pathogens, 2018 Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated.
Charles-Adrien Richard +10 more
doaj +1 more source
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]
, 2011 Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço +21 more
core +1 more source
Folding and Oligomerization of the gp2b/gp3/gp4 Spike Proteins of Equine Arteritis Virus in Vitro
Viruses, 2012 Equine arteritis virus (EAV) is a small, positive-stranded RNA virus. The glycoproteins gp2b, gp3 and gp4 form a heterotrimer in the viral envelope, which is required for cell entry of EAV.
Aleksander Kabatek, Michael Veit
doaj +1 more source
Nature Communications, 2023 Human metapneumovirus (HMPV) is a major cause of respiratory illness in young children. The HMPV polymerase (L) binds an obligate cofactor, the phosphoprotein (P).
Jack D. Whitehead +7 more
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Frontiers in Immunology, 2018 In the search for an eminently practical strategy to develop immunostimulants and vaccines for farmed fish, we have devised recombinant viral antigens presented as “nanopellets” (NPs).
Rosemary Thwaite +8 more
doaj +1 more source
Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. [PDF]
PLoS Pathogens, 2018 Viral invasion triggers the activation of the host antiviral response. Besides the innate immune response, stress granules (SGs) also act as an additional defense response to combat viral replication. However, many viruses have evolved various strategies
Zhulong Hu +5 more
doaj +1 more source