Results 51 to 60 of about 2,533,210 (238)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments
mBio, 2018 RNA viruses that replicate in the cell cytoplasm typically concentrate their replication machinery within specialized compartments. This concentration favors enzymatic reactions and shields viral RNA from detection by cytosolic pattern recognition ...
Bianca S. Heinrich +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Diagnosis of contagious ecthyma in goats in a quarantine station in Panama [PDF]
Revista Mvz Cordoba, 2014 We report an outbreak of contagious ecthyma (CE) in a herd of goats at Paso Canoas quarantine station, Panama. The goats were adult intact females. Visible clinical signs became apparent from day 13 after the start of quarantine.
Angie Magaña Ch. +4 more
doaj +3 more sources
BMC Microbiology, 2003 Background Ebola virus causes severe, often fatal hemorrhagic fever in humans. The mechanism of escape from cellular anti-viral mechanisms is not yet fully understood.
Szekely Laszlo +2 more
doaj +1 more source
The Case of Speech and Language Therapy – Inclusion Ireland [PDF]
, 2014 This short background paper prepared by and with Inclusion Ireland, offers a critical overview of the change process for services for children with disabilities through the microscope of one service: speech and language therapy.
Noone, Simon, Conroy, Pauline
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression [PDF]
, 2015 C.P. was supported by a Ph.D. studentshipfunded by the University of St. Andrews, School of Medicine. I.P. is supported by a Cancer Research UK (CRUK) Ph.D. studentship awarded to J.L.P. and S.R. I.G. and N.C.
Coleman, Nicholas +9 more
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source