Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies. [PDF]
J Virol, 2014 ABSTRACT Cells are equipped with pattern recognition receptors (PRRs) such as the Toll-like and RIG-I-like receptors that mount innate defenses against viruses. However, viruses have evolved multiple strategies to evade or thwart host antiviral responses.
Wu X +8 more
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Advancing the pathologic phenotype of giant axonal neuropathy: early involvement of the ocular lens
Orphanet Journal of Rare Diseases, 2019 Giant axonal neuropathy (GAN; ORPHA: 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of intermediate filaments (IFs).
Diane Armao +5 more
doaj +1 more source
Nature Communications, 2017 Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval +9 more
doaj +1 more source
CRYSTALLINE INTRANUCLEAR INCLUSIONS IN THE RENAL TUBULAR EPITHELIUM OF DOGS [PDF]
Assiut Veterinary Medical Journal, 1987 Intranuclear inclusion bodies with characteristic shape were found in renal tubuler epithelium of dogs. These inclusions were found in 20 out of 50 animals postmortally examined in faculty of Vet. Med. Assiut University.
M.K. IBRAHIM, A.Z. MAHMOUD, A. NAFADY
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Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells. [PDF]
PLoS ONE, 2016 OBJECTIVE:PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs).
Ilker Kudret Sariyer +3 more
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Human Respiratory Syncytial Virus Infection in a Human T Cell Line Is Hampered at Multiple Steps
Viruses, 2021 Human respiratory syncytial virus (HRSV) is the most frequent cause of severe respiratory disease in children. The main targets of HRSV infection are epithelial cells of the respiratory tract, and the great majority of the studies regarding HRSV ...
Ricardo de Souza Cardoso +10 more
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Human Cytomegalovirus. Studies on the Mechanism of Viral Gytopathology and Inclusion Body Formation.
Experimental Biology and Medicine, 1967 SummaryWhen cultured human fetal fi-broblasts were infected by human cytomegalo-virus, virus-induced morphologic changes consisting of cytopathology, intracytoplasmic and intranuclear inclusion bodies developed during a 72-hour period. Thus, in this system, virus-induced cell changes followed closely upon viral multiplication.
R M, McAllister +2 more
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A second cauliflower mosaic virus gene product influences the structure of the viral inclusion body [PDF]
The EMBO Journal, 1984 We have used electron microscopy of thin sections and experiments on isolated viroplasms to compare the properties of four strains of cauliflower mosaic virus (CaMV), three of which were partially or completely deleted in open reading frame (ORF) II. Our results confirm that this gene is required for aphid transmissibility and show that the product of ...
/Givord, Louise +6 more
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RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.
PLoS Pathogens, 2018 Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated.
Charles-Adrien Richard +10 more
doaj +1 more source
Nature Communications, 2023 Human metapneumovirus (HMPV) is a major cause of respiratory illness in young children. The HMPV polymerase (L) binds an obligate cofactor, the phosphoprotein (P).
Jack D. Whitehead +7 more
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