Results 21 to 30 of about 2,533,210 (238)

Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]

, 2011
The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin, Sommer, Marvin, Nour Adel M., Sen Nandini, Wang, Li, Leigh Zerboni, Nandini Sen, Reichelt, Mike, Adel M. Nour, Mike Reichelt, Zerboni, Leigh, Marvin Sommer, Perrino, John, Reichelt Mike, Arvin Ann M., Arvin, Ann M., Ann M Arvin, Nour, Adel M., Baiker, Armin, John Perrino, Zerboni Leigh, Ann M. Arvin, Sommer Marvin, Adel M Nour, Perrino John, Li Wang, Armin Baiker, Sen, Nandini, Wang Li   +28 more
core   +2 more sources

Differential Localization of Structural and Non-Structural Proteins during the Bluetongue Virus Replication Cycle

Viruses, 2020
Members of the Reoviridae family assemble virus factories within the cytoplasm of infected cells to replicate and assemble virus particles. Bluetongue virus (BTV) forms virus inclusion bodies (VIBs) that are aggregates of viral RNA, certain viral ...
Bjorn-Patrick Mohl, Adeline Kerviel, Thomas Labadie, Eiko Matsuo, Polly Roy   +4 more
doaj   +1 more source

Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]

, 2014
This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E, Smith, Matt, Killip, Marian J, Jackson, David   +3 more
core   +1 more source

Formation of large viroplasms and virulence of Cauliflower mosaic virus in turnip plants depend on the N-terminal EKI sequence of viral protein TAV. [PDF]

PLoS ONE, 2017
Cauliflower mosaic virus (CaMV) TAV protein (TransActivator/Viroplasmin) plays a pivotal role during the infection cycle since it activates translation reinitiation of viral polycistronic RNAs and suppresses RNA silencing.
Angèle Geldreich, Gabrielle Haas, Julie Kubina, Clément Bouton, Mélanie Tanguy, Mathieu Erhardt, Mario Keller, Lyubov Ryabova, Maria Dimitrova   +8 more
doaj   +1 more source

Advancing the pathologic phenotype of giant axonal neuropathy: early involvement of the ocular lens

Orphanet Journal of Rare Diseases, 2019
Giant axonal neuropathy (GAN; ORPHA: 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of intermediate filaments (IFs).
Diane Armao, Thomas W. Bouldin, Rachel M. Bailey, Jody E. Hooper, Diana X. Bharucha, Steven J. Gray   +5 more
doaj   +1 more source

ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis [PDF]

, 2013
This work was supported by the Wellcome Trust.Interferon (IFN) induces an antiviral state in cells that results in alterations of the patterns and levels of parainfluenza virus type 5 (PIV5) transcripts and proteins.
Goodbourn, S, Norsted, H., Randall, RE, Andrejeva, J., Thiel, V., Habjan, M, Habjan, M., Goodbourn, S., Norsted, H, Thiel, V, Randall, R. E., Andrejeva, J   +11 more
core   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus

Nature Communications, 2017
Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval, Mickael Lelek, Elyanne Gault, Camille Bouillier, Delphine Sitterlin, Sabine Blouquit-Laye, Marie Galloux, Christophe Zimmer, Jean-François Eleouet, Marie-Anne Rameix-Welti   +9 more
doaj   +1 more source

CRYSTALLINE INTRANUCLEAR INCLUSIONS IN THE RENAL TUBULAR EPITHELIUM OF DOGS [PDF]

Assiut Veterinary Medical Journal, 1987
Intranuclear inclusion bodies with characteristic shape were found in renal tubuler epithelium of dogs. These inclusions were found in 20 out of 50 animals postmortally examined in faculty of Vet. Med. Assiut University.
M.K. IBRAHIM, A.Z. MAHMOUD, A. NAFADY
doaj   +1 more source

Life cycle heterogeneity in animal models of human papillomavirus-associated disease [PDF]

, 2002
Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble
Peh, W.L., Liu, W.J., Christensen, N., Egawa, K., Lewis, J., Christensen, Neil, Peh, Woei Ling, Egawa, Kiyofumi, Percival, Alan, Lewis, Jon, Liu, Wen Jun, Percival, A., Nicholls, Philip, Doorbar, J., Brandsma, Janet, Middleton, K., Nicholls, P.K., Brandsma, J., Middleton, Kate, Sotlar, Karl, Sotlar, K., Doorbar, John   +21 more
core   +1 more source