Results 241 to 250 of about 1,648,672 (312)

Lactylation of the SARS-CoV-2 spike protein is required for viral infection. [PDF]

Signal Transduct Target Ther
Xin J, Wang C, Li Z, Gao W, Zhang W.
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Small Molecule Targeting of Atypical p38 Protects Against Viral Infection. [PDF]

FASEB J
Royer FT, Burton JC, Burns J, Lloyd MG, Onwe R, Moffat JF, Grimsey NJ.   +6 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Small extracellular vesicles from DENV2-infected C6/36 cells show viral infection in vitro and in vivo. [PDF]

Emerg Microbes Infect
Cordero-Rivera CD, Benítez-Vega ML, Palacios-Rápalo SN, Bravo-Silva JJ, Jiménez-Camacho R, Hernández-Castillo J, Pérez-García M, Farfan-Morales CN, De Jesús-González LA, Reyes-Ruiz JM, Osuna-Ramos JF, Medina-Ramirez F, Talamás-Lara D, Cruz-Pérez R, Reyes-Sandoval A, Del Angel RM.   +15 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Risk Factors for Severe Outcomes Among Pediatric Cancer Patients with Respiratory Viral Infection. [PDF]

Microorganisms
Kristal A, Magid A, Arad-Cohen N, Szwarcwort-Cohen M, Shachor-Meyouhas Y.   +4 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Pirfenidone Mitigates Transforming Growth Factor-β-induced Inflammation after Viral Infection. [PDF]

Am J Respir Cell Mol Biol
Thomas BJ, Kan-O K, Gantier MP, Simpson I, Chitty JG, Lam M, Dousha L, Gottschalk TA, Lawlor KE, Tate MD, Ruwanpura S, Seow HJ, Loveland KL, Deshpande S, Li X, Hamza K, King PT, Elias JA, Vlahos R, Bourke JE, Bardin PG.   +20 more
europepmc   +1 more source