Results 21 to 30 of about 3,662,996 (361)

Cumulative exposure to viremia: Methods for the implementation of standardized variables in longitudinal HIV studies

MethodsX, 2023
Measures of viremic exposure over time, including HIV viral copy-years or durable viremic suppression, may be more relevant measures of viral load exposure for comorbid outcomes and mortality than single time point viral load measures. However, there are
Benjamin W. Barrett, Katherine McGowan, Christian Landon, Jinbing Zhang, Sabina Haberlen, Alison G. Abraham   +5 more
doaj   +1 more source

Viral load detection and management on first line ART in rural Rwanda

BMC Infectious Diseases, 2019
Background To achieve the ambitious 90–90-90 UNAIDS targets, access to routine viral load (VL) is critical. To measure VL, Rwanda has relied on a national reference laboratory for years.
Jean de Dieu Ndagijimana Ntwali, Tom Decroo, Muhayimpundu Ribakare, Athanase Kiromera, Placidie Mugwaneza, Sabin Nsanzimana, Lutgarde Lynen   +6 more
doaj   +1 more source

Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events

eLife, 2021
SARS-CoV-2 is difficult to contain because many transmissions occur during pre-symptomatic infection. Unlike influenza, most SARS-CoV-2-infected people do not transmit while a small percentage infect large numbers of people.
Ashish Goyal, D. Reeves, E. F. Cardozo-Ojeja, J. Schiffer, B. Mayer   +4 more
semanticscholar   +1 more source

Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients

Clinical Infectious Diseases, 2020
Background Coronavirus disease 2019 (COVID-19) has become a public health emergency. The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. Methods A total of 323 samples from 76 COVID-19 confirmed
Feng-ting Yu, Liting Yan, Nan Wang, Siyuan Yang, Linghang Wang, Yun-xia Tang, Gui-ju Gao, Sa Wang, Chengjie Ma, R. Xie, Fang Wang, Chianru Tan, Lingxiang Zhu, Yong Guo, Fujie Zhang   +14 more
semanticscholar   +1 more source

Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

medRxiv, 2021
The relationship between SARS-CoV-2 viral load and infectiousness is not known. Using data from a prospective cohort of index cases and high-risk contact, we reconstructed by modelling the viral load at the time of contact and the probability of ...
Aurélien Marc, M. Kerioui, F. Blanquart, J. Bertrand, O. Mitjà, M. Corbacho-Monné, M. Marks, J. Guedj   +7 more
semanticscholar   +1 more source

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Nature Communications, 2020
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity ...
Jesse Fajnzylber, J. Regan, Kendyll Coxen, H. Corry, Colline Wong, A. Rosenthal, Daniel P. Worrall, Francoise F. Giguel, A. Piechocka-Trocha, C. Atyeo, S. Fischinger, Andrew T. Chan, K. Flaherty, K. Hall, M. Dougan, E. Ryan, Elizabeth Gillespie, Rida Chishti, Yijia Li, N. Jilg, D. Hanidziar, R. Baron, L. Baden, Athe M Tsibris, K. Armstrong, D. Kuritzkes, G. Alter, B. Walker, Xu Yu, Jonathan Z. Li, Betelihem A. (Betty) Patrick Diane Alejandro Julia Max Yanni Abayneh Allen Antille Balazs Bals Barbash Bartsch , B. A. Abayneh, P. Allen, Diane Antille, A. Balazs, Julia Bals, M. Barbash, Y. Bartsch, J. Boucau, Siobhan Boyce, J. Braley, Karen Branch, Katherine T. Broderick, J. Carney, Joshua M. Chevalier, M. Choudhary, Navin Chowdhury, T. Cordwell, G. Daley, Susan P Davidson, Michaël Desjardins, Lauren Donahue, David A. Drew, Kevin B. Einkauf, Sampson Elizabeth, Ashley Elliman, B. Etemad, Jonathan K. Fallon, Liz Fedirko, Kelsey K. Finn, J. Flannery, Pamela J Forde, Pilar Garcia-Broncano, E. Gettings, David Golan, Kirsten Goodman, A. Griffin, S. Grimmel, Kathleen A. Grinke, C. Hartana, Michael D Healy, H. Heller, Deborah Henault, Grace Holland, Chenyan Jiang, Hannah Jordan, P. Kaplonek, E. Karlson, Marshall Karpell, Chantal Kayitesi, E. Lam, V. LaValle, Kristina Lefteri, Xiaodong Lian, M. Lichterfeld, D. Lingwood, Hang Liu, Jinqing Liu, Kelly Lopez, Yuting Lu, Sarah Luthern, Ngoc L. Ly, Maureen MacGowan, Karen Magispoc, J. Marchewka, Brittani Martino, R. McNamara, Ashlin R. Michell, Ilan Millstrom, Noah Miranda, Christian Nambu, S. Nelson, Marjorie Noone, L. Novack, C. O’Callaghan, Christine Ommerborn, Matt Osborn, Lois Chris Pacheco, Nicole Phan, S. Pillai, Falisha A Porto, Yelizaveta Rassadkina, Alexandra Reissis, Francis Ruzicka, Kyra W. Seiger, K. Selleck, Libera Sessa, A. Sharpe, C. Sharr, Sally A. Shin, Nishant K. Singh, Sue Slaughenhaupt, K. Sheppard, Weiwei Sun, Xiaoming Sun, Elizabeth Suschana, Opeyemi Talabi, Hannah Ticheli, S. Weiss, Vivine Wilson, A. Zhu   +130 more
semanticscholar   +1 more source

SARS-CoV-2 infectivity by viral load, S gene variants and demographic factors and the utility of lateral flow devices to prevent transmission

medRxiv, 2021
Background: How SARS-CoV-2 infectivity varies with viral load is incompletely understood. Whether rapid point-of-care antigen lateral flow devices (LFDs) detect most potential transmission sources despite imperfect sensitivity is unknown.
Lennard W. Lee, Stefan Rozmanowski, M. Pang, A. Charlett, C. Anderson, G. Hughes, Matthew Barnard, L. Peto, R. Vipond, Alex C. Sienkiewicz, S. Hopkins, J. Bell, D. Crook, N. Gent, A. Walker, T. Peto, D. Eyre   +16 more
semanticscholar   +1 more source

ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens

Emerging Microbes and Infections, 2020
Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which ...
T. Suo, Xinjin Liu, Jiangpeng Feng, M. Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, M. Sajid, Zhi-xiang Huang, Liping Deng, Tie-long Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guo-zhong Chen, K. Lan, Yu Chen   +22 more
semanticscholar   +1 more source

Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing

medRxiv, 2021
Background: Multiple SARS-CoV-2 superspreading events suggest that aerosols play an important role in driving the COVID-19 pandemic. However, the detailed roles of coarse (>5m) and fine ([≤]5m) respiratory aerosols produced when breathing, talking, and ...
K. K. Coleman, D. J. Tay, Kai Sen Tan, S. Ong, Than The Son, Ming Hui Koh, Yi Qing Chin, H. Nasir, T. Mak, J. Chu, D. Milton, V. Chow, P. Tambyah, M. Chen, Tham Kwok Wai   +14 more
semanticscholar   +1 more source

SARS-CoV-2 viral load predicts COVID-19 mortality

The Lancet Respiratory Medicine, 2020
The need for reliable and widely available SARS-CoV-2 testing is well recognized, but it will be equally necessary to develop quantitative methods that determine viral load in order to guide patient triage and medical decision making. We are the first to
E. Pujadas, Fayzan F. Chaudhry, Russell B McBride, F. Richter, Shan Zhao, A. Wajnberg, Girish N. Nadkarni, Benjamin S. Glicksberg, J. Houldsworth, C. Cordon-Cardo   +9 more
semanticscholar   +1 more source