Results 141 to 150 of about 2,160,512 (289)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Viral load suppression and its predictor among HIV seropositive people who receive enhanced adherence counseling at public health institutions in Bahir Dar, Northwest Ethiopia. Retrospective follow-up study.

PLoS ONE
BackgroundFor those HIV seropositive people with high viral loads, the World Health Organization recommends more counseling before changing ART regimens. A high viral load can lead to increased HIV transmission and lower survival rates.
Minyichil Birhanu Belete, Abebayehu Bitew, Kebadnew Mulatu   +2 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Time from HIV diagnosis to viral load suppression: 2007-2012

, 2014
Thesis (Master's)--University of Washington, 2014The HIV care continuum, the steps from diagnosis to engagement in care to viral load suppression, has recently received increased attention.
Gardner Toren, Katelynne
core  

Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: A EuroSIDA study [PDF]

, 2004
BACKGROUND: Factors that determine the immunological response to highly active antiretroviral therapy (HAART) are poorly defined. OBJECTIVE: Our aim was to investigate predictors of immunological failure after initial CD4(+) response.
Horban, A, Mocroft, Amanda, Dragsted, Ulrik Bak, Vella, S, Viard, JP, Lundgren, JD, Vella, Stefano, Viard, Jean-Paul, Machala, Ladislav, Hansen, ABE, Panos, G, Horban, Andrzej, Panos, George, Dragsted, UB, Lundgren, Jens Dilling, Mercey, D, Mocroft, A, Hansen, Ann-Britt E, Machala, L, Mercey, Danielle   +19 more
core  

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Viral load testing, viral suppression and missed appointments pre- and during COVID.

Viral load testing, viral suppression and missed appointments pre- and during COVID.
Nnenna Ezeokafor (16520735), Leila Madueke (18189456), Oluwafemi David Alo (18291017), Sylvia Bolanle Adebajo (18291020), Bazghina-werq Semo (400777), Sylvester Adeyemi (16520738), Ezekiel James (8294973), Cyrus Mugo (4721877), Oluwasanmi Adedokun (294249), Zipporah Kpamor (16520741)   +9 more
core   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Reasons for failure to suppress viral load in patients undergoing antiretroviral therapy

World Journal of Advanced Research and Reviews
Background: Suppressing viral load (VL) is a primary goal of antiretroviral therapy (ART), both for the health of individuals living with HIV and to reduce transmission. However, in the Democratic Republic of Congo (DRC), a significant number of patients do not reach this threshold, which compromises the health gains that have been made.
Nathalie, Mbuyamba Mutombo, Astrid, Lokotshe Kanyama, Dodo, Manda Mukendi, Jirène, Ndjibu Ebondo, Emmanuel, Tshibangu Manyonga, Guy, Kandja Lwamba, Elie, Kabika ya Ntambwe, Odon, Panshi wa Panshi, Jerome, Nyembo Lukamba, Didier, Lubelanu Nkanza, Athy, Kalumba Kambote, Franck, Kasans Tshinyengo, Eric, Kasamba Ilunga, Philomène, Lungu Anzwal   +13 more
openaire   +2 more sources

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source