Results 121 to 130 of about 2,160,512 (289)

Failure to Attain HIV Viral Suppression After Intensified Adherence Counselling—What Can We Learn About Its Factors?

, 2023
James Samwel Mundamshimu,1 Kija Malale,1 Benson R Kidenya,1 Daniel W Gunda,1 Logious Bwemelo,1,* Mwakile Mwashiuya,1,* Salhida Shamnte Omar,1,* Neema Mlowe,1,* Magwa Kiyumbi,1 James S Ngocho,2,3 Emmanuel Balandya,4 Bruno Sunguya,4 Stephen
Mteta K, Kalluvya S, Bartlett J, Mshana SE, Malale K, Omar SS, Kiyumbi M, Lyamuya E, Mwashiuya M, Mmbaga BT, Balandya E, Kidenya BR, Mlowe N, Ngocho JS, Sunguya B, Gunda DW, Mundamshimu JS, Bwemelo L   +17 more
core  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Factors independently associated with viral load suppression.

Factors independently associated with viral load suppression.
N. Mangala (18389158), F. Thienemann (18389170), S. P. Choukem (18389179), D. S. Nsagha (18389176), J. Ateudjieu (18389161), C. Kouanfack (18389164), N. Tendongfor (18389173), S. A. Ndeso (18389152), L. L. Moifo (18389155), A. Dzudie (18389167), C. E. Bekolo (18389149)   +10 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Providing anti-retroviral treatment did not achieve the ambition of ‘Joint united nations program on HIV/AIDS (UNAIDS) among HIV positive patient in Ethiopia’: a systematic review and meta-analysis

Journal of Pharmaceutical Policy and Practice
Introduction: Antiretroviral Treatment (ART) has great importance in reducing viral load. Though a global effort was made to suppress viral load, the level of viral load suppression among ART patients is still high in Ethiopia. Objective: This study aims
Tamirat Melis, Tadesse Sahle, Kassahun Haile, Abebe Timerga, Amare Zewdie, Yohannes Wegu, Kebebush Zepire, Jemal Bedewi   +7 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Virologic Outcomes of Predominantly Tenofovir-Based First-Line Antiretroviral Therapy Among Treatment-Naïve HIV Patients in Davao City, Philippines

Pharmacoepidemiology
Background/Objectives: Tenofovir disoproxil fumarate (TDF)-containing regimens remain the cornerstone of first-line antiretroviral therapy (ART) in many low- and middle-income countries.
Alfredo A. Hinay, Avee Joy B. Dayaganon, Aprilyn F. Francisco-Breva, Jennifer Ashley H. Reyes, Reigner Jay B. Escartin   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Barriers to viral load suppression among adolescents living with HIV on anti-retroviral therapy: a retrospective study in Tanga, Tanzania

AIDS Research and Therapy
Background Despite the decreased incidence of the human immunodeficiency virus (HIV) in Tanzania, the number of adolescents living with HIV is increasing. This study aimed to describe factors independently associated with viral load non-suppression among
Stella Emmanuel Mushy, Expeditho Mtisi, Simon Mkawe, Eric Mboggo, John Ndega, Khadija I. Yahya-Malima, Denice Kamugunya, Edwin Samuel Kilimba, Boniface S. Mlay, Aisa Muya, Frida Ngalesoni   +10 more
doaj   +1 more source

Relationship between HIV viral suppression and multidrug resistant tuberculosis treatment outcomes.

PLOS Global Public Health
The impact of HIV viral suppression on multidrug resistant tuberculosis (MDR-TB) treatment outcomes among people with HIV (PWH) has not been clearly established.
Keri Geiger, Amita Patil, Chakra Budhathoki, Kelly E Dooley, Kelly Lowensen, Norbert Ndjeka, Jacqueline Ngozo, Jason E Farley   +7 more
doaj   +1 more source