Results 111 to 120 of about 2,160,512 (289)

Effects of incentivizing viral suppression in previously incarcerated adults living with HIV

HIV Research & Clinical Practice, 2020
Background: The amount of HIV in a person’s blood can be suppressed to an undetectable level through antiretroviral therapy medications (ART). Adhering to an ART regimen can improve a person’s health and reduce HIV transmission.
Forrest Toegel, August F. Holtyn, Sarah Pollock, Andrew M. Rodewald, Jeannie-Marie Leoutsakos, Michael Fingerhood, Kenneth Silverman   +6 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Long-term durability of HIV viral load suppression [PDF]

The Lancet HIV, 2017
Nila J, Dharan, David A, Cooper
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Benefit of viral load testing for confirmation of immunological failure in HIV patients treated in rural Malawi. [PDF]

, 2011
Objective  Viral load testing is used in the HIV programme of Chiradzulu, Malawi, to confirm the diagnosis of immunological failure to prevent unnecessary switching to second-line therapy.
Robert Mogha, Mar Pujades-Rodríguez, McGuire, Megan, Rupa Kanapathipillai, Pujades-Rodriguez, Mar, Megan McGuire, Annette Heinzelmann, Heinzelmann, Annette, Kanapathipillai, Rupa, Mogha, Robert, Szumilin, Elisabeth, Elisabeth Szumilin   +11 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

HIV Viral Suppression in the Postpartum Year among Women with ≥2 HIV Viral Load Tests.

, 2016
HIV Viral Suppression in the Postpartum Year among Women with ≥2 HIV Viral Load Tests.
Wendy P. Pulver (2938125), Bridget J. Anderson (312488), Louise-Anne McNutt (436257), Lou C. Smith (312495), Victoria Lazariu (2938119), Carol-Ann Swain (2938116), Denis Nash (164689), Guthrie S. Birkhead (2938122), Barbara L. Warren (2938128)   +8 more
core   +1 more source

Correlates of HIV-1 genital shedding in Tanzanian women. [PDF]

, 2011
BACKGROUND: Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who ...
Clare Tanton, David A. Ross, Watson-Jones Deborah, Weiss, Helen A, Watson-Jones, Deborah, Helen A Weiss, Richard J. Hayes, Laurent Belec, Tanton, Clare, Le Goff, Jerome, Hayes, Richard J, Deborah Watson-Jones, Le Goff Jerome, Belec Laurent, Baisley, Kathy, Changalucha John, Weiss Helen A., Everett Dean, Ross, David A, Everett, Dean, David A Ross, Kathy Baisley, Changalucha, John, Mary Rusizoka, Jerome Le Goff, Helen A. Weiss, John Changalucha, Tanton Clare, Dean Everett, Richard J Hayes, Baisley Kathy, Ross David A., Rusizoka, Mary, Rusizoka Mary, Hayes Richard J., Belec, Laurent   +35 more
core   +1 more source

Factors associated with viral load non-suppression among adults with HIV in Sughd region, Tajikistan: a retrospective cohort study

BMC Infectious Diseases
Background Viral load suppression among people living with HIV is a key strategy for reducing HIV transmission. A global target for HIV elimination aims to have 95% of people living with HIV diagnosed, 95% of people diagnosed on antiretroviral therapy ...
Emomali Qurbonov, Dilyara Nabirova, Aisuluu Kubatova, Salomudin Yusufi, Edmond F. Maes, Roberta Horth   +5 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source