Results 91 to 100 of about 2,160,512 (289)

Single Viral Load Measurements Overestimate Stable Viral Suppression Among HIV Patients in Care

, 2016
The HIV continuum of care paradigm uses a single viral load test per patient to estimate the prevalence of viral suppression. We compared this single-value approach with approaches that used multiple viral load tests to examine the stability of ...
Meg Sullivan, Allan Rodriguez, Davila, Jessica, Lytt I. Gardner, Matthew R. Golden, Crepaz, Nicole, Mari-Lynn Drainoni, Stirratt, Michael J, Nicole Crepaz, Christine OʼDaniels, Unnati Patel, Wawrzyniak, Andrew J, William C. Mathews, Mugavero, Michael J, Shireesha Dhanireddy, Edward R. Cachay, Patel, Unnati, OʼDaniels, Christine, Rodriguez, Allan, Dhanireddy, Shireesha, Cynthia Grossman, Andrew J. Wawrzyniak, Rose, Charles E, Cachay, Edward R, Jessica Davila, Lisa R. Metsch, Gary Marks, Giordano, Thomas P, Ellison, Jacqueline, Grossman, Cynthia, Metsch, Lisa R, Thomas P. Giordano, Gardner, Lytt I, Michael J. Mugavero, Sullivan, Meg, Mathews, William C, Golden, Matthew R, Michael J. Stirratt, Marks, Gary, Charles E. Rose, Drainoni, Mari-Lynn, Jacqueline Ellison   +41 more
core   +1 more source

Incidence and Predictors of Viral Load Suppression After Enhanced Adherence Counseling Among HIV-Positive Adults in West Gojjam Zone, Amhara Region, Ethiopia

Infection and Drug Resistance, 2022
Gezahegn Terefe Atnafu,1 Nurilign Abebe Moges,2 Moges Wubie,2 Getnet Gedif2 1Anti-Retroviral Treatment Clinic, Dembecha Health Center, Dembecha, Amhara Region, Ethiopia; 2Department of Public Health, Debre Markos University, Debre Markos, Amhara Region ...
Atnafu GT, Moges NA, Wubie M, Gedif G
doaj  

Risk factors for unsuppressed viral load after intensive adherence counseling among HIV infected persons in Kampala, Uganda: a nested case–control study

AIDS Research and Therapy, 2023
Background Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (ART).
Jonathan Izudi, Barbara Castelnuovo, Rachel King, Adithya Cattamanchi   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Suppression of viral RNA load.

, 2013
A graph of the viral load in the TCR-transduced T-cell mixed cultures relative to those containing untransduced CD8+ T cells is presented. The amount of viral suppression for each culture (viral load of the untransduced CD8+ cells co-culture divided by ...
David E. Ott (88777), Haosi Sun (345677), Eugene V. Barsov (345672), Jacob T. Minang (345676), Matthew T. Trivett (345674), Claes Ohlen (345680)   +5 more
core   +1 more source

Attentional load and sensory competition in human vision: Modulation of fMRI responses by load fixation during task-irrelevant stimulation in the peripheral visual field. [PDF]

, 2005
Perceptual suppression of distractors may depend on both endogenous and exogenous factors, such as attentional load of the current task and sensory competition among simultaneous stimuli, respectively. We used functional magnetic resonance imaging (fMRI)
Schwartz, S., Veilleumier, P., Driver, Jon, Driver, J., Angelo Maravita, Dolan, R. ; https://orcid.org/, Vuilleumier, Patrik, Maravita, A., Dolan, R. J., Jon Driver, Maravita, Angelo, Dolan, R.J., Patrik Vuilleumier, Hutton, Chloe, Vuilleumier, P., Raymond J. Dolan, Schwartz, Sophie, Sophie Schwartz, Hutton, C., Chloe Hutton   +19 more
core   +1 more source

Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy. [PDF]

PLoS ONE, 2014
BACKGROUND:HIV patients on suppressive antiretroviral therapy have undetectable viremia making it impossible to screen plasma HIV tropism if regimen change is required during suppression.
Guinevere Q Lee, Winnie Dong, Theresa Mo, David J H F Knapp, Chanson J Brumme, Conan K Woods, Steve Kanters, Benita Yip, P Richard Harrigan   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A retrospective cross sectional study assessing factors associated with retention and non-viral suppression among HIV positive FSWs receiving antiretroviral therapy from primary health care facilities in Kampala, Uganda

BMC Infectious Diseases, 2022
Background Patient retention in care and sustained viral load suppression are a cornerstone to improved health and quality of life, among people living with HIV. However, challenges of retention on ART remain among female sex workers (FSWs).
Lydia Atuhaire, Constance S. Shumba, Lovemore Mapahla, Peter S. Nyasulu   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source