Results 71 to 80 of about 2,160,512 (289)

Factors associated with HIV RNA viral non-suppression among children and adolescents with HIV attending public health facilities in Gulu City, Uganda: a retrospective cohort study

Therapeutic Advances in Infectious Disease
Background: Human immunodeficiency virus (HIV) RNA viral load testing is the gold standard for monitoring antiretroviral therapy (ART), and sustained viral suppression is critical for preventing HIV-related morbidity and transmission.
Ventrina Lanyero, Felix Bongomin, Daniel S. Ebbs, Ritah Nantale, Emmanuel Ochola   +4 more
doaj   +1 more source

Unsuppressed viral load after intensive adherence counselling in rural eastern Uganda; a case of Kamuli district, Uganda

BMC Public Health, 2021
Background The East Central (EC) region of Uganda has the least viral suppression rate despite having a relatively low prevalence of human immunodeficiency virus (HIV).
Geoffrey Ndikabona, John Bosco Alege, Nicholas Sebuliba Kirirabwa, Derrick Kimuli   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

MONITORING THE VIRAL LOAD IN HIV PATIENTS UNDER ANTI-RETROVIRAL THERAPY (ART) [PDF]

Journal of the Egyptian Society of Parasitology, 2016
Viral load monitoring is an important factor in managing HIV disease. Antiretroviral therapy is the recommended treatment for HIV patients, and the goal therapy is achieving viral suppression and reducing viral load below the level of detection.
ZZA MOHAMED, MAMDOUH EL BAHNASAWY, MARWA AZAB, ALAA EL DIN HOUSNY   +3 more
doaj   +1 more source

Understanding Determinants of Racial and Ethnic Disparities in Viral Load Suppression.

Journal of the International Association of Providers of AIDS Care, 2017
Racial and ethnic disparities in viral load suppression (VLS) have been well documented among people living with HIV (PLWH). The authors hypothesized that a contemporary analytic technique could reveal factors underlying these disparities and provide more explanatory power than broad stereotypes.
Daniel J. Feller BA, Bruce D. Agins MD, MPH   +1 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mixed Longitudinal Regression of Viral Load Suppression.

, 2017
Mixed Longitudinal Regression of Viral Load Suppression.
Bareng Aletta Sanny Nonyane (3738811), Christopher Mathews (595953), John A. Fleishman (599912), Baligh R. Yehia (591734), Richard Rutstein (757316), Richard D. Moore (340677), Jeanne C. Keruly (378445), Stephen A. Berry (599914), Judith A. Aberg (663358), Guy Mahiane (298414), Keri N. Althoff (357209), Ank Nijhawan (757315), Kelly A. Gebo (486297), Allison L. Agwu (599913)   +13 more
core   +1 more source

Disease progression in Human Immunodeficiency Virus type 1 infected viraemic controllers [PDF]

, 2012
PhDBackground: The mechanism of CD4+ T-cell decline in Human Immunodeficiency Virus-1 (HIV-1) infection is unclear, but the association with plasma HIV-1 RNA-load suggests viral replication is involved.
Groves, Katherine Claire
core   +4 more sources

Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic review and meta-analysis

BMC Infectious Diseases
Introduction Previous works of literatures on the viral load suppression rate of third line antiretroviral therapy in Africa has produced inconsistent and inconclusive results, with rates varying between 62% and 95%. This variability poses challenges for
Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh   +18 more
doaj   +1 more source

Time to viral load suppression and its predictors among people living with HIV on antiretroviral therapy in Gebi Resu zone, Afar Region, Ethiopia, 2023

Frontiers in Public Health
ObjectiveThis study aimed to estimate the time to viral load suppression and identify its predictors among HIV patients receiving antiretroviral therapy (ART) in the Gebi Resu zone, Afar Region, Ethiopia, 2023.SettingThe study was conducted at public ...
Anteneh Tefera Chirnet, Ephrem Mannekulih Habtewold, Haji Aman, Elias Bekele Wakwoya, Sewnet Getaye Workie   +4 more
doaj   +1 more source