Results 81 to 90 of about 2,160,512 (289)

Effect of a ward-based outreach team and adherence game on retention and viral load suppression

Southern African Journal of HIV Medicine, 2022
Only 66% of South African people living with HIV (PLWH) are virologically suppressed. Therefore, it is important to develop strategies to improve outcomes.Assess the effect of interventions on 12-month retention in care and virological suppression in participants newly initiated on antiretroviral therapy.Fifty-seven clinics were randomised into four ...
Ngcobo, Sanele, Olorunju, Steve, Nkwenika, Tshifhiwa, Rossouw, Theresa M.   +3 more
openaire   +5 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Socioeconomic determinants of suboptimal adherence to ART and elevated HIV viral load in twelve Sub-Saharan African countries: evidence from population HIV impact assessment survey data

Discover Public Health
Background This study identifies factors influencing viral load suppression among HIV-positive individuals in twelve sub-Saharan African (SSA) countries.
Boniface Simpoli Yohana, John Massito, Arbogast Moshi   +2 more
doaj   +1 more source

Viral load detection and management on first line ART in rural Rwanda

BMC Infectious Diseases, 2019
Background To achieve the ambitious 90–90-90 UNAIDS targets, access to routine viral load (VL) is critical. To measure VL, Rwanda has relied on a national reference laboratory for years.
Jean de Dieu Ndagijimana Ntwali, Tom Decroo, Muhayimpundu Ribakare, Athanase Kiromera, Placidie Mugwaneza, Sabin Nsanzimana, Lutgarde Lynen   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]

, 2002
This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Klauke, S, Royal Free Ctr HIV Med Goethe Univ, Phillips, AN, Bickel, M, Johnson, MA, Doerr, HW, Youle, MS, Loveday, C, Miller, V, Lampe, F, Staszewski, S, Sabin, CA   +11 more
core  

Accuracy of Provider Predictions of Viral Suppression Among Adolescents and Young Adults With HIV in an HIV Clinical Program

Journal of the International Association of Providers of AIDS Care
Background Providers caring for adolescents and young adults with HIV (AYA-HIV) mostly base their adherence counseling during clinical encounters on clinical judgment and expectations of patients’ medication adherence.
Johannes Thrul PhD, Hasiya Yusuf MD, MPH, Janardan Devkota MS, MPH, Jill Owczarzak PhD, MA, Elise Tirza Ohene-Kyei MD, MPH, Kelly Gebo MD, MPH, Allison Agwu MD, ScM, FAAP, FIDSA   +6 more
doaj   +1 more source

Reduction in time to viral suppression among persons living with HIV in Jamaica between 2017-2019.

PLOS Global Public Health
IntroductionHIV viral suppression is important for effective treatment and for reducing new infections. In 2019, only 66% of persons on antiretroviral treatment (ART) in Jamaica were virally suppressed.
Anya Cushnie, Ralf Reintjes, Miia Artama, J Peter Figueroa   +3 more
doaj   +1 more source

Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages

Biochemistry and Biophysics Reports, 2017
Monocytes serve as sanctuary sites for HIV-1 from which virus is difficult to be eliminated. Therefore, an effective viral suppression in monocytes is critical for effective antiretroviral therapy (ART). This study focuses on a new strategy using nanoformulation to optimize the efficacy of ART drugs in HIV-infected monocytes.Poly(lactic-co-glycolic ...
Yuqing Gong, Pallabita Chowdhury, Narasimha M. Midde, Mohammad A. Rahman, Murali M. Yallapu, Santosh Kumar   +5 more
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source