Results 61 to 70 of about 131,769 (294)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Changing how the third 95 is counted: suitable indicators for measuring U = U with findings from Taiwan

AIDS Research and Therapy
Introduction The World Health Organisation has implemented multiple HIV prevention policies and strived to achieve the 90-90-90 goal by 2020, achieving the 95-95-95 goal by 2030, which refers to 95% of patients living with HIV knowing their HIV status ...
Hsun-Yin Huang, Yu-Ching Huang, Hsiu-Yun Lo, Pei-Chun Chan, Chia-Chi Lee   +4 more
doaj   +1 more source

Risk factors for unsuppressed viral load after intensive adherence counseling among HIV infected persons in Kampala, Uganda: a nested case–control study

AIDS Research and Therapy, 2023
Background Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (ART).
Jonathan Izudi, Barbara Castelnuovo, Rachel King, Adithya Cattamanchi   +3 more
doaj   +1 more source

Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa. [PDF]

, 2004
OBJECTIVE: To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa.
Asselman, V, Boulle, A, Coetzee, D, Goemaere, E, Hildebrand, K, Van Cutsem, G   +5 more
core   +1 more source

Cost-effectiveness of a nurse-based intervention (AIMS) to improve adherence among HIV-infected patients : Design of a multi-centre randomised controlled trial [PDF]

, 2013
Peer reviewedPublisher ...
de Bruin, Marijn, Evers, Silvia, Gras, Luuk, McCambridge, Jim, Nobel, Hans-Erik, Oberje, Edwin, Prins, Jan, Schaalma, Herman, Tousset, Eric, Viechtbauer, Wolfgang   +9 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A retrospective cross sectional study assessing factors associated with retention and non-viral suppression among HIV positive FSWs receiving antiretroviral therapy from primary health care facilities in Kampala, Uganda

BMC Infectious Diseases, 2022
Background Patient retention in care and sustained viral load suppression are a cornerstone to improved health and quality of life, among people living with HIV. However, challenges of retention on ART remain among female sex workers (FSWs).
Lydia Atuhaire, Constance S. Shumba, Lovemore Mapahla, Peter S. Nyasulu   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Viral load detection and management on first line ART in rural Rwanda

BMC Infectious Diseases, 2019
Background To achieve the ambitious 90–90-90 UNAIDS targets, access to routine viral load (VL) is critical. To measure VL, Rwanda has relied on a national reference laboratory for years.
Jean de Dieu Ndagijimana Ntwali, Tom Decroo, Muhayimpundu Ribakare, Athanase Kiromera, Placidie Mugwaneza, Sabin Nsanzimana, Lutgarde Lynen   +6 more
doaj   +1 more source

Factors associated with HIV viral suppression among adolescents in Kabale district, South Western Uganda.

PLoS ONE, 2022
BackgroundThe goal of antiretroviral therapy is to achieve sustained human immune deficiency virus (HIV) viral suppression. However, research on factors associated with viral load suppression among adolescents in low and middle-income countries is ...
Tugume Peterson Gordon, Muhwezi Talbert, Maud Kamatenesi Mugisha, Ainamani Elvis Herbert   +3 more
doaj   +1 more source