Results 71 to 80 of about 131,769 (294)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Incidence and Predictors of Viral Load Suppression After Enhanced Adherence Counseling Among HIV-Positive Adults in West Gojjam Zone, Amhara Region, Ethiopia

Infection and Drug Resistance, 2022
Gezahegn Terefe Atnafu,1 Nurilign Abebe Moges,2 Moges Wubie,2 Getnet Gedif2 1Anti-Retroviral Treatment Clinic, Dembecha Health Center, Dembecha, Amhara Region, Ethiopia; 2Department of Public Health, Debre Markos University, Debre Markos, Amhara Region ...
Atnafu GT, Moges NA, Wubie M, Gedif G
doaj  

Viral Suppression and Its Associated Factors in HIV Patients on Highly Active Antiretroviral Therapy (HAART): A Retrospective Study in the Ho Municipality, Ghana

AIDS Research and Treatment, 2020
Background. The WHO targets to end HIV/AIDS as a public health problem by 2030. The introduction of the ambitious “90-90-90” strategy to attain this target is expected to be achieved by the year 2020.
Sylvester Yao Lokpo, Patrick Jnr Ofori-Attah, Louis Selassie Ameke, Christian Obirikorang, Verner Ndudiri Orish, Godsway Edem Kpene, Eric Agboli, Gideon Kye-Duodu, John Gameli Deku, Benedict Kwame Awadzi, Mark Noagbe, Seyram Tetteh Quarshie   +11 more
doaj   +1 more source

Adherence to antiretroviral therapy and viral suppression: Analysis of three periods between 2011 and 2017 at an HIV-AIDS center, Brazil

Frontiers in Pharmacology, 2023
The increased effectiveness of antiretroviral therapy (ART) in the last 30 years is a scientific landmark, and viral suppression is directly associated with treatment adherence.
Micheline Marie Milward de Azevedo Meiners, Micheline Marie Milward de Azevedo Meiners, Igor Araújo Cruz, Maria Inês de Toledo   +3 more
doaj   +1 more source

Overview of Factors Associated with HIV Viral Load Suppression in Transgender Women

The Journal of Applied Laboratory Medicine, 2020
Abstract Background Transgender women face a significantly higher HIV burden than their cisgender counterparts around the world with worse treatment outcomes in almost all categories. Content A mini-review of the available literature ...
openaire   +2 more sources

Single Viral Load Measurements Overestimate Stable Viral Suppression Among HIV Patients in Care: Clinical and Public Health Implications [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016
Background: The HIV continuum of care paradigm uses a single viral load test per patient to estimate the prevalence of viral suppression. We compared this single-value approach with approaches that used multiple viral load tests to examine the stability of suppression.
Gary, Marks, Unnati, Patel, Michael J, Stirratt, Michael J, Mugavero, William C, Mathews, Thomas P, Giordano, Nicole, Crepaz, Lytt I, Gardner, Cynthia, Grossman, Jessica, Davila, Meg, Sullivan, Charles E, Rose, Christine, OʼDaniels, Allan, Rodriguez, Andrew J, Wawrzyniak, Matthew R, Golden, Shireesha, Dhanireddy, Jacqueline, Ellison, Mari-Lynn, Drainoni, Lisa R, Metsch, Edward R, Cachay   +20 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals [PDF]

, 2018
Background: Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted ...
Blanco, Julià, Crespo, Manel, De Clercq, Laura, Gálvez, Cristina, Jimenez, Montse, Martinez-Picado, Javier, Moron-Lopez, Sara, Navarro, Jordi, Puertas, Maria C, Ribas, Bibiana Planas, Rutsaert, Sofie, Salgado, Maria, Torrella, Ariadna, Universitat Autònoma de Barcelona, Urrea, Víctor, Vandekerckhove, Linos   +15 more
core   +3 more sources

Beyond viral suppression of HIV – the new quality of life frontier [PDF]

, 2016
BACKGROUND: In 2016, the World Health Organization (WHO) adopted a new Global Health Sector Strategy on HIV for 2016–2021. It establishes 15 ambitious targets, including the ‘90-90-90’ target calling on health systems to reduce under-diagnosis of HIV ...
Baptista-Leite, R, Barton, SE, Costagliola, D, Dedes, N, del Amo Valero, J, Gatell, JM, Lazarus, JV, Mendao, L, Porter, K, Rockstroh, JK, Safreed-Harmon, K, Vella, S   +11 more
core   +9 more sources