Results 81 to 90 of about 131,769 (294)

Socioeconomic determinants of suboptimal adherence to ART and elevated HIV viral load in twelve Sub-Saharan African countries: evidence from population HIV impact assessment survey data

Discover Public Health
Background This study identifies factors influencing viral load suppression among HIV-positive individuals in twelve sub-Saharan African (SSA) countries.
Boniface Simpoli Yohana, John Massito, Arbogast Moshi   +2 more
doaj   +1 more source

Reduction in time to viral suppression among persons living with HIV in Jamaica between 2017-2019.

PLOS Global Public Health
IntroductionHIV viral suppression is important for effective treatment and for reducing new infections. In 2019, only 66% of persons on antiretroviral treatment (ART) in Jamaica were virally suppressed.
Anya Cushnie, Ralf Reintjes, Miia Artama, J Peter Figueroa   +3 more
doaj   +1 more source

HIV dynamics and natural history studies: Joint modeling with doubly interval-censored event time and infrequent longitudinal data

, 2011
Hepatitis C virus (HCV) coinfection has become one of the most challenging clinical situations to manage in HIV-infected patients. Recently the effect of HCV coinfection on HIV dynamics following initiation of highly active antiretroviral therapy (HAART)
Hogan, Joseph W., Su, Li
core   +1 more source

Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region [PDF]

, 2016
To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses ...
Arvind H Patel, Emma C Thomson, Gavin S Wilkie, John eMcLauchlan, Joseph eHughes, Mark W Robinson, Mark W Robinson, Peter R Mills, Rachael eSwann, Rachael eSwann, Stephen T Barclay   +10 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Accuracy of Provider Predictions of Viral Suppression Among Adolescents and Young Adults With HIV in an HIV Clinical Program

Journal of the International Association of Providers of AIDS Care
Background Providers caring for adolescents and young adults with HIV (AYA-HIV) mostly base their adherence counseling during clinical encounters on clinical judgment and expectations of patients’ medication adherence.
Johannes Thrul PhD, Hasiya Yusuf MD, MPH, Janardan Devkota MS, MPH, Jill Owczarzak PhD, MA, Elise Tirza Ohene-Kyei MD, MPH, Kelly Gebo MD, MPH, Allison Agwu MD, ScM, FAAP, FIDSA   +6 more
doaj   +1 more source

Effectiveness of a community-based intervention (Konga model) to address factors contributing to low viral load suppression among children living with HIV in Tanzania: a preliminary, cluster, randomized clinical trial report

BMC Public Health, 2023
Background Despite effective antiretroviral therapy (ART) coverage in other groups living with human immunodeficiency virus (HIV) in Tanzania, virologic suppression among HIV-positive children receiving ART remains unacceptably low.
Kihulya Mageda, Khamis Kulemba, Edwin Kilimba, Leornard K. Katalambula, Ntuli Kapologwe, Pammla Petrucka   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Time taken to reach undetectable viral loads in therapy-naïve HIV patients commencing ART [PDF]

, 2015
Peer reviewedPublisher ...
Baguley, Steve, Brawley, Daniela, Butt, Ambreen, Ismail, Muhammad A, Okpo, Emmanuel, Tonna, Ivan   +5 more
core  

Life Chaos is Associated with Reduced HIV Testing, Engagement in Care, and ART Adherence Among Cisgender Men and Transgender Women upon Entry into Jail. [PDF]

, 2020
Life chaos, the perceived inability to plan for and anticipate the future, may be a barrier to the HIV care continuum for people living with HIV who experience incarceration. Between December 2012 and June 2015, we interviewed 356 adult cisgender men and
Cunningham, William E, Ettner, Susan L, Garland, Wendy H, Harawa, Nina T, Shoptaw, Steve J, Takada, Sae   +5 more
core