Results 1 to 10 of about 254,857 (183)

Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C. [PDF]

mBio, 2022
FMDV is the leading cause of the foot-and-mouth disease (FMD), affecting cloven-hoofed animals with high morbidity and mortality. We determined that HSP60 is required for efficient viral RNA replication and mRNA translation during FMDV infection ...
Tang J, Abdullah SW, Li P, Wu J, Pei C, Mu S, Wang Y, Sun S, Guo H.   +8 more
europepmc   +2 more sources

Human Enterovirus Group B Viruses Rely on Vimentin Dynamics for Efficient Processing of Viral Nonstructural Proteins. [PDF]

J Virol, 2020
A virus needs the host cell in order to replicate and produce new progeny viruses. For this, the virus takes over the host cell and modifies it to become a factory for viral proteins.
Turkki P, Laajala M, Flodström-Tullberg M, Marjomäki V.   +3 more
europepmc   +2 more sources

Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection [PDF]

Viruses, 2021
Dengue virus (DENV) infection causes a spectrum of dengue diseases that have unclear underlying mechanisms. Nonstructural protein 1 (NS1) is a multifunctional protein of DENV that is involved in DENV infection and dengue pathogenesis.
Thanyaporn Dechtawewat, S. Roytrakul, Y. Yingchutrakul, Sawanya Charoenlappanit, Bunpote Siridechadilok, T. Limjindaporn, Arunothai Mangkang, Tanapan Prommool, C. Puttikhunt, P. Songprakhon, Kessiri Kongmanas, Nuttapong Kaewjew, Panisadee Avirutnan, P. Yenchitsomanus, P. Malasit, S. Noisakran   +15 more
semanticscholar   +4 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +2 more sources

Peptides targeting dengue viral nonstructural protein 1 inhibit dengue virus production [PDF]

Scientific Reports, 2020
Viruses manipulate the life cycle in host cells via the use of viral properties and host machineries. Development of antiviral peptides against dengue virus (DENV) infection has previously been concentrated on blocking the actions of viral structural ...
P. Songprakhon, Thanawat Thaingtamtanha, T. Limjindaporn, C. Puttikhunt, C. Srisawat, Prasit Luangaram, Thanyaporn Dechtawewat, C. Uthaipibull, Sissades Thongsima, P. Yenchitsomanus, P. Malasit, S. Noisakran   +11 more
semanticscholar   +3 more sources

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

Viruses, 2022
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova, Elizaveta Starodubova, Vadim Karpov   +2 more
doaj   +2 more sources

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +4 more sources

Functional studies of the coronavirus nonstructural proteins

STEMedicine, 2020
Coronaviruses, including SARS-CoV, SARS-CoV-2, and MERS-CoV, have caused contagious and fatal respiratory diseases in humans worldwide. Notably, the coronavirus disease 19 (COVID-19) caused by SARS-CoV-2 spread rapidly in early 2020 and became a global ...
Yanglin Qiu, Kai Xu
doaj   +2 more sources

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories [PDF]

Journal of Virology
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly.
Raquel Tenorio, Gwen M. Taylor, Ana Cayuela, C. O. S. Sorzano, Isabel Fernández de Castro, Sara Y. Fernández-Sánchez, Alexa N. Roth, Xayathed Somoulay, Gavin S. Treadaway, Terence S. Dermody, Cristina Risco   +10 more
doaj   +2 more sources

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +4 more sources