Results 11 to 20 of about 254,896 (222)

Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development [PDF]

Frontiers in Cellular and Infection Microbiology
Zika virus (ZIKV) causes severe neurological disease, including microcephaly and Guillain-Barré syndrome, through complex interactions with host cell proteins.
Xiaodong Han, Jiansen Du, Wenhui Li, Shuqian Yang, Huamuzi Sun, Guihua Wang, Haolong Cong   +6 more
doaj   +2 more sources

Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA.

Virology, 2007
Alphaviruses are a group of arthropod-borne human and animal pathogens that can cause epidemics of significant public health and economic consequence. Alphavirus RNA synthesis requires four virally encoded nonstructural proteins and probably a number of cellular proteins.
Andrew J. Burnham, Lei Gong, R. Hardy
semanticscholar   +3 more sources

Reovirus Nonstructural Protein σNS Acts as an RNA Stability Factor Promoting Viral Genome Replication [PDF]

Journal of Virology, 2018
Following infection, viruses synthesize nonstructural proteins that mediate viral replication and promote dissemination. Viruses from the family Reoviridae encode nonstructural proteins that are required for the formation of progeny viruses.
Paula F. Zamora, Liya Hu, J. J. Knowlton, R. Lahr, R. Moreno, Andrea J. Berman, B. Prasad, T. Dermody   +7 more
semanticscholar   +3 more sources

Foot-and-mouth disease virus 3C protease as virulence determinant plays multiple roles in cleaving viral polyprotein and host factors [PDF]

Virulence
Foot-and-mouth disease virus (FMDV) can cause a severe infectious disease that primarily affects even-toed ungulates. FMDV is classified into the genus of Aphthovirus in the family Picornaviridae.
Houcheng Zhou, Mengyao Wang, Zuo Xin, Zhijuan Li, Qianqian Wang, Yan Li, Fuxiao Liu   +6 more
doaj   +2 more sources

Flavivirus nonstructural proteins and replication complexes as antiviral drug targets.

Current Opinion in Virology, 2023
Many flaviviruses are well-known pathogens, such as dengue, Zika, Japanese encephalitis, and yellow fever viruses. Among them, dengue viruses cause global epidemics and threaten billions of people. Effective vaccines and antivirals are in desperate need.
Kaïn van den Elsen, Bing Liang Alvin Chew, J. Ho, D. Luo   +3 more
semanticscholar   +1 more source

Structural and nonstructural proteins of Senecavirus A: Recent research advances, and lessons learned from those of other picornaviruses.

Virology, 2023
Senecavirus A (SVA) is an emerging virus, causing vesicular disease in swine. SVA is a single-stranded, positive-sense RNA virus, which is the only member of the genus Senecavirus in the family Picornaviridae. SVA genome encodes 12 proteins: L, VP4, VP2,
Qianqian Wang, Hailan Meng, Dong-yu Ge, H. Shan, Letu Geri, Fuxiao Liu   +5 more
semanticscholar   +1 more source

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis [PDF]

Cell Host & Microbe, 2019
Murine norovirus (MNoV) infects a low percentage of enteric tuft cells and can persist in these cells for months following acute infection. Both tuft-cell tropism and resistance to interferon-λ (IFN-λ)-mediated clearance during persistent infection requires the viral nonstructural protein 1/2 (NS1/2).
Sanghyun, Lee, Hejun, Liu, Craig B, Wilen, Zoi E, Sychev, Chandni, Desai, Barry L, Hykes, Robert C, Orchard, Broc T, McCune, Ki-Wook, Kim, Timothy J, Nice, Scott A, Handley, Megan T, Baldridge, Gaya K, Amarasinghe, Herbert W, Virgin   +13 more
openaire   +2 more sources

Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis [PDF]

Journal of Virology, 2006
ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the ...
Hilda, Montero, Carlos F, Arias, Susana, Lopez   +2 more
openaire   +2 more sources

Flavivirus Capsid Proteins Inhibit the Interferon Response

Viruses, 2022
Zika virus (ZIKV) establishes persistent infections in multiple human tissues, a phenomenon that likely plays a role in its ability to cause congenital birth defects and neurological disease. Multiple nonstructural proteins encoded by ZIKV, in particular
Adriana M. Airo, Alberto Felix-Lopez, Valeria Mancinelli, Danyel Evseev, Joaquin Lopez-Orozco, Kathy Shire, Patrick Paszkowski, Lori Frappier, Katharine E. Magor, Tom C. Hobman   +9 more
doaj   +1 more source

SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation

Microorganisms, 2021
Viral infection-induced activation of inflammasome complexes has both positive and negative effects on the host. Proper activation of inflammasome complexes induces down-stream effector mechanisms that inhibit viral replication and promote viral ...
Na-Eun Kim, Dae-Kyum Kim, Yoon-Jae Song
semanticscholar   +1 more source