Results 31 to 40 of about 254,896 (222)

Mitophagy induced by classical swine fever virus nonstructural protein 5A promotes viral replication

Virus Research, 2022
The classical swine fever virus (CSFV) is one of the most harmful pathogens of swine and causes considerable economic loss. Mitophagy is a selective form of autophagy that degrades damaged mitochondria by combining with lysosomes. Previous studies have been reported that CSFV infection can induce mitophagy, but which effector protein is responsible for
Zhang, Chengcheng, Wang, Xiuling, Sun, Jiahao, Guo, Mengjiao, Zhang, Xiaorong, Wu, Yantao   +5 more
openaire   +2 more sources

Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]

PLoS ONE, 2015
Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan, Jie Zhang, Hong Guo, Shicui Yan, Qingxiu Chen, Fuxian Zhang, Qin Fang   +6 more
doaj   +1 more source

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment [PDF]

Cell Reports, 2019
The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 component) binding and envelopment.
Kumar, Sathish, Barouch-Bentov, Rina, Xiao, Fei, Schor, Stanford, Pu, Szuyuan, Biquand, Elise, Lu, Albert, Lindenbach, Brett, Jacob, Yves, Demeret, Caroline, Einav, Shirit   +10 more
openaire   +4 more sources

Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis

Viruses, 2023
The porcine reproductive and respiratory syndrome virus (PRRSV) causes economic losses in the swine industry worldwide. However, current vaccines cannot provide effective protection against PRRSV, and PRRSV-specific treatments for infected herds are ...
Zhenbang Zhu, Yuqian Xu, Lulu Chen, Meng Zhang, Xiangdong Li   +4 more
doaj   +1 more source

Role of nonstructural proteins in the pathogenesis of SARS‐CoV‐2

Journal of Medical Virology, 2020
We read with great interest the study authored by Angeletti et al. regarding the role of nonstructural proteins nsp2 and nsp3 in the pathogenesis of COVID-191 .
Severino Jefferson Ribeiro da Silva, C. T. A. da Silva, R. Mendes, L. Pena   +3 more
semanticscholar   +1 more source

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing [PDF]

Journal of Virology, 1995
A transient protein expression system in COS-1 cells was used to study the role of hepatitis C virus (HCV)-encoded NS4A protein on HCV nonstructural polyprotein processing. By analyzing the protein expression and processing of a deletion mutant polypeptide, NS delta 4A, which encodes the entire putative HCV nonstructural polyprotein except the region ...
Y, Tanji, M, Hijikata, S, Satoh, T, Kaneko, K, Shimotohno   +4 more
openaire   +2 more sources

Structural biology of SARS-CoV-2: open the door for novel therapies

Signal Transduction and Targeted Therapy, 2022
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent of the pandemic disease COVID-19, which is so far without efficacious treatment.
Weizhu Yan, Yanhui Zheng, Xiaotao Zeng, Bin He, Wei Cheng   +4 more
doaj   +1 more source

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

bioRxiv, 2020
The COVID-19 pandemic affects millions of people worldwide with a rising death toll. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uses its nonstructural protein 1 (Nsp1) to redirect host translation machinery to the ...
S. Yuan, Lei Peng, Jonathan J. Park, Yingxia Hu, S. Devarkar, Matthew B Dong, Shenping Wu, Sidi Chen, I. Lomakin, Y. Xiong   +9 more
semanticscholar   +1 more source

Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread

Viruses, 2011
Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15 to 20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread through contact with bodily fluids containing infected cells, most often from
Patrick L. Green, Nadine Bowden, Michael D. Lairmore, Lee Ratner, Rashade A. H. Haynes II, Robyn Haines, Rajaneesh Anupam   +6 more
doaj   +1 more source

Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection [PDF]

Journal of Virology, 2019
MEV causes fatal hemorrhagic enteritis in minks. Apoptosis is a cellular mechanism that effectively sacrifices virus-infected cells to maintain homeostasis between the virus and host. In this study, we demonstrated that MEV induces apoptosis both in vivo and in vitro .
Peng Lin, Yuening Cheng, Shanshan Song, Jianming Qiu, Li Yi, Zhigang Cao, Jianrong Li, Shipeng Cheng, Jianke Wang   +8 more
openaire   +2 more sources