Results 41 to 50 of about 254,896 (222)

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses

PLoS Pathogens, 2019
Human respiratory syncytial virus (RSV) is the most important cause of acute lower respiratory tract disease in infants worldwide. As a first line of defense against respiratory infections, innate immune responses, including the production of type I and ...
Koen Sedeyn, Bert Schepens, X. Saelens
semanticscholar   +1 more source

The Expression and Function of the Small Nonstructural Proteins of Adeno-Associated Viruses (AAVs)

Viruses
Adeno-associated viruses (AAVs) are small, non-enveloped viruses that package a single-stranded (ss)DNA genome of 4.7 kilobases (kb) within their T = 1 icosahedral capsid.
Cagla Aksu Kuz, Shane McFarlin, Jianming Qiu   +2 more
doaj   +1 more source

Nucleocytoplasmic Shuttling of Influenza A Virus Proteins

Viruses, 2015
Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus.
Jing Li, Meng Yu, Weinan Zheng, Wenjun Liu   +3 more
doaj   +1 more source

Interactome profile of the host cellular proteins and the nonstructural protein 2 of porcine reproductive and respiratory syndrome virus. [PDF]

PLoS ONE, 2014
The nonstructural protein 2 (NSP2) is considered to be one of crucial viral proteins in the replication and pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV).
Li Wang, Lei Zhou, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang   +7 more
doaj   +1 more source

The effects of autophagy on the replication of Nelson Bay orthoreovirus

Virology Journal, 2019
Background Nelson Bay orthoreovirus (NBV) was first isolated over 40 years ago from a fruit bat in Australia. Normally, NBV does not cause human diseases, but recently several NBV strains have been associated with human respiratory tract infections, thus
Xiao-Li Tao, Wei Zhao, Wei Tong, Xiao-Fang Wang, Li-Li Dou, Jiang-Man Chen, Nian Liu, Ying Lu, Yi-Bo Zhang, Xu-Peng Jin, Yan-Fei Shen, Hong-Yan Zhao, Hong Jin, Yong-Gang Li   +13 more
doaj   +1 more source

Recent insights into the structure and function of coronavirus ribonucleases

FEBS Open Bio, 2022
Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response.
Meredith N. Frazier, Amanda A. Riccio, Isha M. Wilson, William C. Copeland, Robin E. Stanley   +4 more
doaj   +1 more source

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

Cell Discovery, 2017
Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evade antiviral responses from host cells.
Yaoxing Wu, Qingxiang Liu, Jie Zhou, Weihong Xie, Cheng Chen, Zefang Wang, Haitao Yang, J. Cui   +7 more
semanticscholar   +1 more source

Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies

Viruses
Viral replicons are efficient tools to understand the mechanisms of viral replication and screen antiviral drugs. In this study, a viral-cDNA-based replicon of Japanese encephalitis virus (JEV), which is the causative agent of Japanese encephalitis, was ...
Yang Yang, Jiayang Zheng, Yafang Lin, Yan Zhang, Qianming Zhao, Hailong Zhang, Junjie Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zhiyong Ma, Jianchao Wei   +13 more
doaj   +1 more source

Cellular protein HSC70 promotes fowl adenovirus serotype 4 replication in LMH cells via interacting with viral 100K protein

Poultry Science, 2022
: Fowl adenovirus serotype 4 (FAdV-4), the predominant causative agent of hepatitis-hydropericardium syndrome (HHS), has caused severe economic losses to poultry industry since 2015.
Shenyan Gao, Huayuan Chen, Xiaozhan Zhang, Jun Zhao, Zeng Wang   +4 more
doaj   +1 more source

Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells

Microbiology Spectrum, 2022
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global outbreak and prompted an enormous research effort.
Anita E. Grootemaat, Sanne van der Niet, Edwin R. Scholl, Eva Roos, Bernadette Schurink, Marianna Bugiani, Sara E. Miller, Per Larsen, Jeannette Pankras, Eric A. Reits, Nicole N. van der Wel   +10 more
doaj   +1 more source