Results 61 to 70 of about 35,570 (216)

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Suppression of TRIM19 by arterivirus nonstructural protein 1 promotes viral replication

Virus Research
Tripartite motif (TRIM)-containing proteins are a family of regulatory proteins that can participate in the induction of antiviral cytokines and antagonize viral replication. Promyelocytic leukemia (PML) protein is known as TRIM19 and is a major scaffold protein organizing the PML nuclear bodies (NBs).
Chia-Ming Su, Yu Fan Hung, Junyu Tang, Mingyuan Han, Roger Everett, Dongwan Yoo   +5 more
openaire   +3 more sources

HUMAN CYTOMEGALOVIRUS-SPECIFIC CYTO-TOXIC T-CELLS - RELATIVE FREQUENCY OF STAGE-SPECIFIC CTL RECOGNIZING THE 72-KD IMMEDIATE EARLY PROTEIN AND GLYCOPROTEIN-B EXPRESSED BY RECOMBINANT VACCINIA VIRUSES [PDF]

, 1988
CTL are held to be an important host defense mechanism in persistent herpes-virus infections. We have therefore studied the nature and specificity of human cytomegalovirus (HCMV)-specific CTL in normal persistently infected individuals. This was achieved
J K Hickling, Smith, GL, Sinclair, J, J G Sissons, Borysiewicz, LK, J Sinclair, S Graham, G L Smith, L K Borysiewicz, Hickling, JK, Sissons, JG, M P Cranage, Cranage, MP, Graham, S   +13 more
core   +1 more source

Recent insights into the structure and function of coronavirus ribonucleases

FEBS Open Bio, 2022
Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response.
Meredith N. Frazier, Amanda A. Riccio, Isha M. Wilson, William C. Copeland, Robin E. Stanley   +4 more
doaj   +1 more source

Cellular protein HSC70 promotes fowl adenovirus serotype 4 replication in LMH cells via interacting with viral 100K protein

Poultry Science, 2022
: Fowl adenovirus serotype 4 (FAdV-4), the predominant causative agent of hepatitis-hydropericardium syndrome (HHS), has caused severe economic losses to poultry industry since 2015.
Shenyan Gao, Huayuan Chen, Xiaozhan Zhang, Jun Zhao, Zeng Wang   +4 more
doaj   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1

The Journal of Infectious Diseases
Abstract Background Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role of dengue nonstructural protein-1 (NS1) antibodies are not well understood.
Michelle Premazzi Papa, Evelyn Mendoza-Torres, Peifang Sun, Liliana Encinales, Joseph Goulet, Gabriel Defang, Jani Vihasi, Ying Cheng, Karol Suchowiecki, Wendy Rosales, Richard Amdur, Alexandra Porras-Ramirez, Alejandro Rico-Mendoza, Carlos Herrera Gomez, Samuel Nicholes, Ivan Zuluaga, Liam Halstead, Scott Halstead, Gary Simon, Kevin Porter, Rebecca M Lynch, Aileen Y Chang   +21 more
openaire   +2 more sources

Coalescence of the sites of cowpea mosaic virus RNA replication into a cytopathic structure [PDF]

, 2002
Cowpea mosaic virus (CPMV) replication induces an extensive proliferation of endoplasmic reticulum (ER) membranes, leading to the formation of small membranous vesicles where viral RNA replication takes place.
Carette, J.E., Gühl, K., Wellink, J., Kammen, A., van   +3 more
core   +1 more source

Unlocking the secrets of Feline calicivirus: advances in structural and nonstructural proteins and its role as a key model for other Caliciviruses

Virology Journal
Feline calicivirus (FCV) is a highly contagious pathogen responsible for respiratory infections, lingual ulceration, oral ulcers and systemic diseases in cats, posing a significant risk to feline family worldwide.
Sana Asif, Deng Yingkun, Chunchun Meng
doaj   +1 more source

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.

PLoS Pathogens, 2013
The nonstructural protein NS5A has emerged as a new drug target in antiviral therapies for Hepatitis C Virus (HCV) infection. NS5A is critically involved in viral RNA replication that takes place at newly formed membranes within the endoplasmic reticulum
Dorothee A Vogt, Grégory Camus, Eva Herker, Brian R Webster, Chia-Lin Tsou, Warner C Greene, Tien-Sze Benedict Yen, Melanie Ott   +7 more
doaj   +1 more source