Results 71 to 80 of about 2,054,524 (213)

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome [PDF]

, 2007
The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.
Brunn, Albrecht von, Teepe, Carola, Caroline C Friedel, Ralph Baric, Haas, Jürgen, von Brunn, Albrecht, Simpson Jeremy C., Jeremy C. Simpson, Simpson, Jeremy C., Ralf Zimmer, Roberts, Rhonda, Carola Teepe, Rainer Pepperkok, Baric Ralph, Haas Jürgen, Simpson, Jeremy, Zimmer, Ralf, Zimmer Ralf, Caroline C. Friedel, Friedel, Caroline C., Haas, Juergen, Teepe Carola, Albrecht von Brunn, Rhonda Roberts, Jürgen Haas, Friedel Caroline C., Pepperkok Rainer, Pepperkok, Rainer, Roberts Rhonda, Baric, Ralph, Jeremy C Simpson, von Brunn Albrecht   +31 more
core   +1 more source

The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2

Journal of Virology
Porcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai, Shujie Wang, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Qian Wang, Rui Huang, Cui-Hong Rao, Shi-Jia Xu, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai, Yan-Dong Tang   +12 more
doaj   +1 more source

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

mBio, 2023
Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis.
Samantha L. Grimes, Young J. Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Jennifer Gribble, Andrea J. Pruijssers, Maria L. Agostini, Alexandra Abu-Shmais, Xiaotao Lu, Seth A. Darst, Elizabeth Campbell, Mark R. Denison   +12 more
doaj   +1 more source

Hemipteran vectors of stylet‐borne plant viruses: Aphids lead the charge

Insect Science, EarlyView.
Among all sap‐feeding hemipterans, aphids stand out by far as the most important vectors of noncirculative plant viruses. Compared to whiteflies and mealybugs, aphids’ highly specialized stylet anatomy and distinct feeding behaviors contribute, together with other features of their biology, to their remarkable efficiency in transmitting stylet‐borne ...
Yu Fu, Stefano Colella, Marilyne Uzest
wiley   +1 more source

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing [PDF]

Journal of Virology, 1995
A transient protein expression system in COS-1 cells was used to study the role of hepatitis C virus (HCV)-encoded NS4A protein on HCV nonstructural polyprotein processing. By analyzing the protein expression and processing of a deletion mutant polypeptide, NS delta 4A, which encodes the entire putative HCV nonstructural polyprotein except the region ...
Y, Tanji, M, Hijikata, S, Satoh, T, Kaneko, K, Shimotohno   +4 more
openaire   +2 more sources

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.

PLoS Pathogens, 2019
Hepatitis C virus (HCV) assembly and envelopment are coordinated by a complex protein interaction network that includes most of the viral structural and nonstructural proteins.
Allison E Roder, Christine Vazquez, Stacy M Horner   +2 more
doaj   +1 more source

Effects of Atmospheric CO2 Levels on the Susceptibility of Maize to Diverse Pathogens

Plant, Cell &Environment, EarlyView.
ABSTRACT Rising atmospheric CO2 has significant implications for crop productivity and food security. Based on studies in C3 plants, elevated CO2 (eCO2) can shape plant‐pathogen interactions, although the outcomes are often variable. The question of how eCO2 influences immunity and disease development in C4 plants, such as the globally important cereal
Ekkachai Khwanbua, Yunhui Qi, John Ssengo, Peng Liu, Michelle A. Graham, Steven A. Whitham   +5 more
wiley   +1 more source

Discovery of BPR2-D2 compound in inhibiting Chikungunya viral RNA synthesis by replicon systems

Biomedical Journal
Chikungunya virus (CHIKV), an alphavirus in the Togaviridae family, is transmitted to humans through mosquito bites and can lead to severe complications in newborns and elders.
Yi-Ju Hsu, Tram-Anh Thi Phan, Hui-Chung Lin, Der-Jiang Chiao, Szu-Cheng Kuo, Syh-Jae Lin, Rei-Lin Kuo   +6 more
doaj   +1 more source

Design, evaluation, and validation of specific primers for accurate detection of VHS virus in rainbow trout (Oncorhynchus mykiss)

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract Accurate detection of Piscine novirhabdovirus (PNRV), also know as viral hemorrhagic septicemia virus (VHSV) in rainbow trout (Oncorhynchus mykiss) is essential for effective aquaculture disease management. This study developed strain‐inclusive primers targeting the conserved glycoprotein (G) gene using integrated bioinformatics approaches ...
Mohammad Kazem Momeni, Mohsen Mobini‐Dehkordi, Amin Nematollahi   +2 more
wiley   +1 more source