Results 91 to 100 of about 35,570 (216)

Proteolytic Processing of Rubella Virus Nonstructural Proteins [PDF]

, 1998
The genomic RNA of rubella virus contains two long open reading frames (ORF), a 5′-proximal ORF that codes for the nonstructural proteins and a 3′-proximal ORF that encodes the structural proteins.
Hwang, Dorothy, Liang, Yuying, Gillam, Shirley, Chong, Pele, Yao, Jiansheng, Yang, Decheng   +5 more
core   +1 more source

Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles

Viruses, 2019
Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation ...
Raquel Tenorio, Isabel Fernández de Castro, Jonathan J. Knowlton, Paula F. Zamora, Danica M. Sutherland, Cristina Risco, Terence S. Dermody   +6 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Akabane virus nonstructural protein NSm regulates viral growth and pathogenicity in a mouse model

Journal of Veterinary Medical Science, 2016
The biological function of a nonstructural protein, NSm, of Akabane virus (AKAV) is unknown. In this study, we generated a series of NSm deletion mutant viruses by reverse genetics and compared their phenotypes. The mutant in which the NSm coding region was almost completely deleted could not be rescued, suggesting that NSm plays a role in virus ...
ISHIHARA, Yukari, SHIODA, Chieko, BANGPHOOMI, Norasuthi, SUGIURA, Keita, SAEKI, Kohei, TSUDA, Shumpei, IWANAGA, Tatsuya, TAKENAKA-UEMA, Akiko, KATO, Kentaro, MURAKAMI, Shin, UCHIDA, Kazuyuki, AKASHI, Hiroomi, HORIMOTO, Taisuke   +12 more
openaire   +3 more sources

A Single Point Mutation in Nonstructural Protein NS2 of Bovine Viral Diarrhea Virus Results in Temperature-Sensitive Attenuation of Viral Cytopathogenicity [PDF]

Journal of Virology, 2009
ABSTRACTForBovine viral diarrhea virus(BVDV), the type species of the genusPestivirusin the familyFlaviviridae, cytopathogenic (cp) and noncytopathogenic (ncp) viruses are distinguished according to their effect on cultured cells. It has been established that cytopathogenicity of BVDV correlates with efficient production of viral nonstructural protein ...
Alexander, Pankraz, Simone, Preis, Heinz-Jürgen, Thiel, Andreas, Gallei, Paul, Becher   +4 more
openaire   +2 more sources

Recent Advances in Dengue Fever Based on Serotypes, Virulence Factors, Prevention, and Treatment: A Comprehensive Review [PDF]

Disease and Diagnosis
Dengue fever, a Flaviviridae viral disease, exhibits various clinical symptoms, such as hemorrhagic fever, and is influenced by multiple factors. This comprehensive review aims to explore different aspects of dengue fever.
Ali Salimi Asl, Narjes Seddighi, Amir Mohammad Barani, Mahla Naderi Nasab, Elham Barahimi   +4 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection [PDF]

, 1984
The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection.
Koszinowski, Ulrich H., Ebeling-Keil, Angelika, Keil, Günther M.   +2 more
core  

Japanese Encephalitis Virus and Host Innate Immunity: Insights Into TLR Signaling, PRR Crosstalk, and Viral Immune Evasion

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by pattern‐recognition receptors such as Toll‐like receptors (TLRs) and RIG‐I–like receptors, play critical ...
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama‐Kohara   +2 more
wiley   +1 more source

The HLA-II immunopeptidome of SARS-CoV-2

Cell Reports
Summary: Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavirus 2
Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti   +14 more
doaj   +1 more source