Results 81 to 90 of about 35,570 (216)

Dengue virus NS4B protein as a target for developing antivirals

Frontiers in Cellular and Infection Microbiology, 2022
Dengue virus is an important pathogen affecting global population while no specific treatment is available against this virus. Effort has been made to develop inhibitors through targeting viral nonstructural proteins such as NS3 and NS5 with enzymatic ...
Qingxin Li, Congbao Kang
doaj   +1 more source

Hemipteran vectors of stylet‐borne plant viruses: Aphids lead the charge

Insect Science, EarlyView.
Among all sap‐feeding hemipterans, aphids stand out by far as the most important vectors of noncirculative plant viruses. Compared to whiteflies and mealybugs, aphids’ highly specialized stylet anatomy and distinct feeding behaviors contribute, together with other features of their biology, to their remarkable efficiency in transmitting stylet‐borne ...
Yu Fu, Stefano Colella, Marilyne Uzest
wiley   +1 more source

The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal [PDF]

, 2012
Transcription termination of the mRNA produced from the small (S) genome segment of Bunyamwera orthobunyavirus (BUNV) has previously been mapped to two cis-acting sequences located within the 5′ UTR using a virus-free replication assay.
Elliott, Richard Michael, Blakqori, G., Lowen, Anice C., Lowen, A.C., Elliott, R.M., Blakqori, Gjon   +5 more
core   +1 more source

RETRACTED: PERK Is Critical for Alphavirus Nonstructural Protein Translation [PDF]

, 2021
Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes encephalitis. Previous work indicated that VEEV infection induced early growth response 1 (EGR1) expression, leading to cell death via the protein kinase R (PKR)-like endoplasmic ...
Lauren Panny, Ivan Akhrymuk, Caitlin Lehman, Nishank Bhalla, Jonathan Jacobs, Nicole Bracci, Kylene Kehn-Hall, Michael Barrera, Jonathan Dinman, Bibha Dahal   +9 more
core   +1 more source

Effects of Atmospheric CO2 Levels on the Susceptibility of Maize to Diverse Pathogens

Plant, Cell &Environment, EarlyView.
ABSTRACT Rising atmospheric CO2 has significant implications for crop productivity and food security. Based on studies in C3 plants, elevated CO2 (eCO2) can shape plant‐pathogen interactions, although the outcomes are often variable. The question of how eCO2 influences immunity and disease development in C4 plants, such as the globally important cereal
Ekkachai Khwanbua, Yunhui Qi, John Ssengo, Peng Liu, Michelle A. Graham, Steven A. Whitham   +5 more
wiley   +1 more source

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Delayed by Design: Role of Suboptimal Signal Peptidase Processing of Viral Structural Protein Precursors in Flaviviridae Virus Assembly

Viruses, 2020
The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant morbidity and mortality in humans and other mammals, including ruminants and pigs.
Nabeel Alzahrani, Ming-Jhan Wu, Saravanabalaji Shanmugam, MinKyung Yi   +3 more
doaj   +1 more source

Genomic and Epidemiological Characterization of DENV‐1 and DENV‐2 Co‐Circulation During the 2023–2024 Dengue Epidemic in Espírito Santo, Brazil

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT In 2023 and 2024, Espírito Santo state, Brazil, experienced its largest dengue epidemic in 30 years, with record numbers of cases and deaths. This study aimed to characterize confirmed dengue cases and the dengue virus (DENV) during the epidemic and pre‐epidemic periods.
Nicolli Ribeiro de Jesus, Caio Santos de Souza, Mariene R. Amorim, João Paulo Cola, Raquel Gomes Catozo, Bruno Luiz M. Guedes, Bruna Caetano Pimenta, Julia Sthefany Nunes Zordan, Yasmim Barcellos Madeira Rosa, Henrique Tamanini Silva Moschen, Aline Souza Areias, Tatiane Comerio, Isabela Valim Sarmento, Julia Miranda Fardin, Daniel Claudio de Oliviera Gomes, Kiven Kumar, Eng Eong Ooi, Camila Malta Romano, Creuza Rachel Vicente   +18 more
wiley   +1 more source

Design and Synthesis of Novel Imidazo[4,5‐c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I. Kalliampakou, Eirini P. Kollia, Eleni V. Mikropoulou, Maria Halabalaki, Christos T. Chasapis, Niki Vassilaki, Nikolaos Lougiakis   +10 more
wiley   +1 more source

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins [PDF]

Journal of Virology, 2016
ABSTRACT A novel chimeric parvoviral vector, rAAV2/HBoV1, in which the recombinant adeno-associated virus 2 (rAAV2) genome is pseudopackaged by the human bocavirus 1 (HBoV1) capsid, has been shown to be highly efficient in gene delivery to human airway epithelia (Z.
Wei, Zou, Fang, Cheng, Weiran, Shen, John F, Engelhardt, Ziying, Yan, Jianming, Qiu   +5 more
openaire   +2 more sources