Results 81 to 90 of about 47,745 (223)

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Reovirus Nonstructural Protein σNS Acts as an RNA Stability Factor Promoting Viral Genome Replication [PDF]

Journal of Virology, 2018
Following infection, viruses synthesize nonstructural proteins that mediate viral replication and promote dissemination. Viruses from the family Reoviridae encode nonstructural proteins that are required for the formation of progeny viruses. Although nonstructural proteins of different viruses in the family
Paula F, Zamora, Liya, Hu, Jonathan J, Knowlton, Roni M, Lahr, Rodolfo A, Moreno, Andrea J, Berman, B V Venkataram, Prasad, Terence S, Dermody   +7 more
openaire   +2 more sources

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses [PDF]

, 2017
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-
Brennan, Benjamin, Elliott, Richard M., Rezelj, Veronica V.   +2 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1

The Journal of Infectious Diseases
Abstract Background Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role of dengue nonstructural protein-1 (NS1) antibodies are not well understood.
Michelle Premazzi Papa, Evelyn Mendoza-Torres, Peifang Sun, Liliana Encinales, Joseph Goulet, Gabriel Defang, Jani Vihasi, Ying Cheng, Karol Suchowiecki, Wendy Rosales, Richard Amdur, Alexandra Porras-Ramirez, Alejandro Rico-Mendoza, Carlos Herrera Gomez, Samuel Nicholes, Ivan Zuluaga, Liam Halstead, Scott Halstead, Gary Simon, Kevin Porter, Rebecca M Lynch, Aileen Y Chang   +21 more
openaire   +2 more sources

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Carbajo-Lozoya, Javier, Dall'Armi, Ekatarina von, Ditt, Vanessa, Drosten, Christian, Friedel, Caroline C., Haas, Juergen G., Herrler, Georg, Herzog, Petra, Hilgenfeld, Rolf, Kallies, Stefan, Kuri, Thomas, Kögl, Manfred, Müller, Marcel A., Niemeyer, Daniela, Pfefferle, Susanne, Pumpor, Ksenia, Pöhlmann, Stefan, Schwarz, Frank, Schwegmann-Wessels, Christel, Schöpf, Julia, Steffen, Imke, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Thiel, Volker, Weber, Friedemann, Zimmer, Ralf, Züst, Roland   +27 more
core   +1 more source

Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles

Viruses, 2019
Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation ...
Raquel Tenorio, Isabel Fernández de Castro, Jonathan J. Knowlton, Paula F. Zamora, Danica M. Sutherland, Cristina Risco, Terence S. Dermody   +6 more
doaj   +1 more source

Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice

Microorganisms, 2020
Kunjin virus (KUNV) is an attenuated strain of the severe neurotropic West Nile virus (WNV). The virus has a single-strand positive-sense RNA genome that encodes a polyprotein.
Pham-Tue-Hung Tran, Naveed Asghar, Urban Höglund, Olivia Larsson, Lars Haag, Ali Mirazimi, Magnus Johansson, Wessam Melik   +7 more
doaj   +1 more source

Hemipteran vectors of stylet‐borne plant viruses: Aphids lead the charge

Insect Science, EarlyView.
Among all sap‐feeding hemipterans, aphids stand out by far as the most important vectors of noncirculative plant viruses. Compared to whiteflies and mealybugs, aphids’ highly specialized stylet anatomy and distinct feeding behaviors contribute, together with other features of their biology, to their remarkable efficiency in transmitting stylet‐borne ...
Yu Fu, Stefano Colella, Marilyne Uzest
wiley   +1 more source