Results 111 to 120 of about 2,054,524 (213)

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Scientific Reports
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection.
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran   +13 more
openaire   +3 more sources

Subcellular location and protein interactions of the infectious bronchitis virus gene 3 and 5 accessory proteins [PDF]

The avian coronavirus infectious bronchitis virus (IBV) expresses four nonstructural, non-gene 1 proteins (3a, 3b, 5a and 5b) which have been shown to be dispensable for virus replication in cell culture.
Davies, Marc Tudor
core  

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core   +1 more source

A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect.

PLoS Pathogens, 2020
Herpes simplex virus type 1 (HSV1) is a complicated structural agent with a sophisticated transcription process and a high infection rate. A vaccine against HSV1 is urgently needed.
Xingli Xu, Xiao Feng, Lichun Wang, Ting Yi, Lichun Zheng, Guorun Jiang, Shengtao Fan, Yun Liao, Min Feng, Ying Zhang, Dandan Li, Qihan Li   +11 more
doaj   +1 more source

Implicações do peptídeo conservado E250-270 da proteína "E" na infectividade do vírus da dengue [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014Os vírus de genoma RNA apresentam uma ampla variabilidade genética, devido à ...
Fleith, Renata Cristina
core  

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Interfering with interferon: developing a reporter system to study the interaction between hepatitus C viral proteins and the interferon signalling pathway [PDF]

, 2008
PhDThe aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatment. This involved the development of novel testing systems and their application to patient samples.
Jones, Meleri
core   +3 more sources

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Virulence
Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune ...
Xiaolong Lu, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu   +3 more
doaj   +1 more source

Foot-and-mouth disease virus 3C protease as virulence determinant plays multiple roles in cleaving viral polyprotein and host factors

Virulence
Foot-and-mouth disease virus (FMDV) can cause a severe infectious disease that primarily affects even-toed ungulates. FMDV is classified into the genus of Aphthovirus in the family Picornaviridae.
Houcheng Zhou, Mengyao Wang, Zuo Xin, Zhijuan Li, Qianqian Wang, Yan Li, Fuxiao Liu   +6 more
doaj   +1 more source

Spontaneous HCV clearance: an association with gender, age, viral genotypes, infection transmission routes, and markers of HBV and HIV

Терапевтический архив, 2010
Aim. To determine the rate of spontaneous recovery depending on gender, age, prior icteric hepatitis, infection transmission routes, HCV genotype, markers of HBV and HIV. Subjects and methods. A humoral immunity response to core antigen and nonstructural
Sergey Valer'evich Fedorchenko, T L Martynovich, O V Lyashok, Zh A Karyuk, V I Yanchenko, S V Fedorchenko, T L Martynovich, O V Lyashok, Zh A Karyuk, V I Yanchenko   +9 more
doaj