Results 111 to 120 of about 35,570 (216)

Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C. [PDF]

mBio, 2022
Tang J, Abdullah SW, Li P, Wu J, Pei C, Mu S, Wang Y, Sun S, Guo H.   +8 more
europepmc   +1 more source

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Münch, Konrad, Koszinowski, Ulrich H., Messerle, Martin, Keil, Günther M.   +3 more
core   +1 more source

A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect.

PLoS Pathogens, 2020
Herpes simplex virus type 1 (HSV1) is a complicated structural agent with a sophisticated transcription process and a high infection rate. A vaccine against HSV1 is urgently needed.
Xingli Xu, Xiao Feng, Lichun Wang, Ting Yi, Lichun Zheng, Guorun Jiang, Shengtao Fan, Yun Liao, Min Feng, Ying Zhang, Dandan Li, Qihan Li   +11 more
doaj   +1 more source

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Scientific Reports
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection.
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran   +13 more
openaire   +3 more sources

Mapping mutational fitness effects across the coxsackievirus B3 proteome reveals distinct profiles of mutation tolerability.

PLoS Biology
RNA viruses have notoriously high mutation rates due to error-prone replication by their RNA polymerase. However, natural selection concentrates variability in a few key viral proteins.
Beatriz Álvarez-Rodríguez, Sebastian Velandia-Álvarez, Christina Toft, Ron Geller   +3 more
doaj   +1 more source

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core  

The regulation of type I interferon production by paramyxoviruses [PDF]

, 2009
Research supported by The Wellcome Trust (087751/A/08/Z)Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha ...
Goodbourn, S, Richard E. Randall, Stephen Goodbourn, Randall, Richard Edward   +3 more
core   +1 more source

Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering

Journal of Virology
Alphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici, Danni Yong, Silvia M. Vidal, GuanQun Liu   +3 more
doaj   +1 more source

Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments [PDF]

, 2010
Since 1998, several serotypes of Bluetongue virus (BTV) have invaded several southern European countries. In 2006, the unknown BTV serotype 8 (BTV8/net06) unexpectedly invaded North-West Europe and has resulted in the largest BT-outbreak ever recorded ...
Veldman, D., van de Water, S.G.P., René GP van Gennip, van de Water Sandra GP, Veldman Daniel, Piet A van Rijn, Rijn, P.A., van, Daniel Veldman, van Gennip, H.G.P., Gennip, H.G.P., van, van Gennip René GP, van Rijn Piet A, Water, S.G.P., van de, Sandra GP van de Water, van Rijn, P.A.   +14 more
core   +1 more source

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]

, 1991
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schlicht, Hans-Jürgen, Ruppert, Thomas   +4 more
core   +1 more source