Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]
, 2010 Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA [PDF]
, 1990 We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication.
Niesters, Hubert G. M. +1 more
core +2 more sources
Regulation of positive-strand RNA virus replication: The emerging role of phosphorylation. [PDF]
, 2007 Protein phosphorylation is a reversible post-translational modification that plays a fundamental role in the regulation of many cellular processes.
Jakubiec, Anna, Jupin, Isabelle
core +3 more sources
A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect.
PLoS Pathogens, 2020 Herpes simplex virus type 1 (HSV1) is a complicated structural agent with a sophisticated transcription process and a high infection rate. A vaccine against HSV1 is urgently needed.
Xingli Xu +11 more
doaj +1 more source
Characterizing the turnover of viral nonstructural proteins of the hepatitis C virus
, 2022 After infection of the host cell, the RNA of the hepatitis C virus (HCV) is translated to the polyprotein followed by cleavage into the structural and nonstructural proteins. The structural proteins are released as viral particles from the host cell, while the equimolar amount of produced nonstructural proteins remain in the cell.
openaire +2 more sources
Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C. [PDF]
mBio, 2022 Tang J +8 more
europepmc +1 more source
The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker [PDF]
, 2013 The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and mechanistic function have remained somewhat elusive ever since it was first reported in 1970 as a viral antigen circulating in the sera of dengue-infected patients.
Muller, David A., Young, Paul R.
core +1 more source
PLoS BiologyRNA viruses have notoriously high mutation rates due to error-prone replication by their RNA polymerase. However, natural selection concentrates variability in a few key viral proteins.
Beatriz Álvarez-Rodríguez +3 more
doaj +1 more source
Akabane virus nonstructural protein NSm regulates viral growth and pathogenicity in a mouse model
Journal of Veterinary Medical Science, 2016 The biological function of a nonstructural protein, NSm, of Akabane virus (AKAV) is unknown. In this study, we generated a series of NSm deletion mutant viruses by reverse genetics and compared their phenotypes. The mutant in which the NSm coding region was almost completely deleted could not be rescued, suggesting that NSm plays a role in virus ...
ISHIHARA, Yukari +12 more
openaire +3 more sources