Results 121 to 130 of about 47,745 (223)

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +2 more sources

Nonstructural 5A Protein of Hepatitis C Virus Interacts with Pyruvate Carboxylase and Modulates Viral Propagation

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the N-terminal region of NS5A and the biotin carboxylase domain of PC.
Yim, Seung-Ae, Lim, Yun-Sook, Kim, Jong-Wook, Hwang, Soon B.   +3 more
openaire   +5 more sources

The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Virulence
Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune ...
Xiaolong Lu, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu   +3 more
doaj   +1 more source

Complete Genome Sequence of a Putative Densovirus of the Asian Citrus Psyllid, Diaphorina citri. [PDF]

, 2016
Here, we report the complete genome sequence of a putative densovirus of the Asian citrus psyllid, Diaphorina citri Diaphorina citri densovirus (DcDNV) was originally identified through metagenomics, and here, we obtained the complete nucleotide sequence
Falk, Bryce W, Nigg, Jared C, Nouri, Shahideh   +2 more
core   +1 more source

Foot-and-mouth disease virus 3C protease as virulence determinant plays multiple roles in cleaving viral polyprotein and host factors

Virulence
Foot-and-mouth disease virus (FMDV) can cause a severe infectious disease that primarily affects even-toed ungulates. FMDV is classified into the genus of Aphthovirus in the family Picornaviridae.
Houcheng Zhou, Mengyao Wang, Zuo Xin, Zhijuan Li, Qianqian Wang, Yan Li, Fuxiao Liu   +6 more
doaj   +1 more source

MicroRNA-like viral small RNA from porcine reproductive and respiratory syndrome virus negatively regulates viral replication by targeting the viral nonstructural protein 2

Oncotarget, 2016
Many viruses encode microRNAs (miRNAs) that are small non-coding single-stranded RNAs which play critical roles in virus-host interactions. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically impactful viruses in the swine industry.
Li, Na, Yan, Yunhuan, Zhang, Angke, Gao, Jiming, Zhang, Chong, Wang, Xue, Hou, Gaopeng, Zhang, Gaiping, Jia, Jinbu, Zhou, En-Min, Xiao, Shuqi   +10 more
openaire   +3 more sources

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]

, 2014
The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A, Johnston, SL, Mousnier, A, Pinto, A, Rogers, AV, Solari, R, Swieboda, D, Walton, R   +7 more
core   +2 more sources

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Scientific Reports
Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection.
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran   +13 more
openaire   +3 more sources

Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review

Frontiers in Immunology
Newcastle disease (ND) is one of the most serious viral diseases affecting chickens and is caused by Newcastle disease virus (NDV), an avian paramyxovirus serotype-1.
Haile Berihulay, Haile Berihulay, Wei Luo, Ainong Lao, Jian Ji, Manshan Cai, Dingming Shu, Chenglong Luo   +7 more
doaj   +1 more source

Aptamer as a therapeutic agent for dengue infections

Virology Journal
Dengue virus (DENV) poses a significant global health burden, with current treatments being limited and primarily supportive. Aptamers are an emerging class of molecular recognition elements that are cheaper, less immunogenic and have no batch-to-batch ...
Nur Aida Laili Mislan, Citartan Marimuthu, Amir Muhaimin Akmal Shukri, Jeyanthi Suppiah, Rozainanee Mohd Zain, Fadzilah Mohd Nor, Seok Mui Wang   +6 more
doaj   +1 more source