Results 171 to 180 of about 4,116,626 (248)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, Volume 7, Issue 5, October 2026.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Analysis of Virologic and Clinical Predictors for Hospitalization, Supported by Machine Learning, in a Phase 3 Molnupiravir COVID‐19 Treatment Trial

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Machine learning (ML) is increasingly being used in clinical medicine. The objective of this study was to identify factors predictive of hospitalization, with the support of ML, in outpatients with mild‐to‐moderate COVID‐19. Unvaccinated adults with mild‐to‐moderate COVID‐19 were randomized 1:1 to molnupiravir or placebo in MOVe‐OUT ...
Matthew G. Johnson, Jessica M. Conway, Laura E. Liao, David W. Hilbert, Erin Jensen, Dorothy McCoy, Yanfen Guan, Ying Zhang, Michelle L. Brown, Dana D. Byrne, Carisa De Anda   +10 more
wiley   +1 more source

Characterisation of HIV‐1 Gag Cytotoxic T‐Lymphocyte Epitopes in the Southern African Region—A Systematic Review

Immunology, Volume 179, Issue 2, Page 165-184, October 2026.
Distribution of studies on HIV‐1 Gag cytotoxic T‐lymphocyte epitopes in the southern African region showing that the majority of studies (58.44%) were conducted in South Africa, followed by Botswana (15.58%), Zambia (10.39%), Malawi (7.79%), Zimbabwe (6.49%), and Angola (1.30%).
Tumelo L. Fortuin, Paballo Nkone, Shayne Loubser, Caroline T. Tiemessen, Simnikiwe H. Mayaphi   +4 more
wiley   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, Volume 252, Issue 2, Page 797-816, October 2026.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. See also the Commentary on this article by May & Nagy, 252: 525–527. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions ...
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion, Volume 66, Issue 10, Page 1993-2006, October 2026.
Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean‐Michel Pawlotsky, Syria Laperche, Daniel Candotti   +8 more
wiley   +1 more source

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

, 2023
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Chang T, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvardo RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP.   +26 more
europepmc   +1 more source

PARP3 Promotes SARS-CoV-2 Replication via Interaction with the Viral Nucleocapsid Protein. [PDF]

Kobe J Med Sci
Adyaksa DNM, Rhamadianti AF, Deng L, Abe T, Matsui C, Shoji I.   +5 more
europepmc   +1 more source

PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein. [PDF]

PLoS Pathog
Wu HY, Zhong SY, Qi AS, Wang ZR, Tu QS, Li F, Wu R, Wang JY, Song F, Zhang TY, Li T, Yu QC, Yuan HM, Lv DM, Ouyang HS, Du XL, Pang DX, Xie ZC.   +17 more
europepmc   +1 more source

PABPC1 Restricts Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection via TOLLIP-Mediated Degradation of Viral Nucleocapsid Protein. [PDF]

Pathogens
Sun M, Yuan C, Zhang Y, Zhu X, Shi L, Duan Y, Mao W, Li L, Liu Y, Wang Q.   +9 more
europepmc   +1 more source

The PCK2-Traf6-Tollip Axis Restricts PEDV Replication by Orchestrating Selective Autophagic Degradation of the Viral Nucleocapsid Protein. [PDF]

Transbound Emerg Dis
Gao A, Yang X, Qin W, Zheng D, Liu Y, Sun H, Chen Z, Tong G, Xue S, Kong N, Zheng L.   +10 more
europepmc   +1 more source