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Transcription Regulatory Sequences in Coronaviruses: Mechanistic Foundations for Antivirals and Vaccines. [PDF]

J Microbiol Biotechnol
Myoung J.
europepmc   +1 more source

The Coronavirus Nucleocapsid Is a Multifunctional Protein

Viruses, 2014
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly ...
Burtram C Fielding
exaly   +3 more sources

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Mouse Hepatitis Virus Nucleocapsid Protein as a Translational Effector of Viral mRNAs

Advances in Experimental Medicine and Biology, 1998
The mouse hepatitis virus (MHV) nucleocapsid protein stimulated translation of a chimeric reporter mRNA containing an intact MHV 5'-untranslated region and the chloramphenicol acetyltransferase (CAT) coding region. The nucleocapsid protein binds specifically the tandemly repeated-UCYAA- of the MHV leader. This RNA sequence is the same as the intergenic
Stephen A Stohlman, S A Stohlman
exaly   +3 more sources

SARS-CoV-2 nucleocapsid protein: Importance in viral infection

JUSTC, 2022
The coronavirus disease 2019 (COVID-19) epidemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of deaths worldwide. Therefore, it is critical to understand the biological basis of SARS-CoV-2 to develop novel approaches to control its spread.
H. M. Shifa ul Haq, Arnaud John KOMBE KOMBE, Ayesha Zahid, Momal Babar, Weihong Zeng, Hongliang He, Tengchuan Jin   +6 more
openaire   +1 more source

Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replication

Trends in Biochemical Sciences, 1998
Retrovirus particles contain a small, basic protein, the nucleocapsid (NC) protein, that possesses 'nucleic acid chaperone' activity--that is, the NC protein can catalyze the rearrangement of a nucleic acid molecule into the conformation that has the maximal number of base pairs.
Judith G Levin, Alan Rein, L E Henderson
exaly   +3 more sources

Small viral RNA segment of bunyaviruses codes for viral nucleocapsid protein

Journal of Virology, 1978
Tryptic peptide analyses have been undertaken on the nucleocapsid (N) protein of snowshoe hare (SSH) and La Crosse (LAC) bunyaviruses. Similar analyses have been performed on the N proteins of two recombinant viruses which have the large/medium/small RNA genome configurations: SSH/LAC/LAC and SSH/LAC/SSH.
J R, Gentsch, D H, Bishop
openaire   +2 more sources