Results 111 to 120 of about 1,219,846 (287)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
A low-background, fluorescent assay to evaluate inhibitors of diverse viral proteases. [PDF]
J Virol, 2023 Leonard RA +6 more
europepmc +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases
Viruses, 2019 Many plant viruses express their proteins through a polyprotein strategy, requiring the acquisition of protease domains to regulate the release of functional mature proteins and/or intermediate polyproteins.
Krin S. Mann, Hélène Sanfaçon
doaj +1 more source
Regulation of Autophagosome–Lysosome Fusion by Human Viral Infections [PDF]
Autophagy plays a fundamental role in maintaining cellular homeostasis by eliminating intracellular components via lysosomes. Successful degradation through autophagy relies on the fusion of autophagosomes to lysosomes, which leads to the formation of ...
Po-Yuan Ke
core +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors [PDF]
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke +2 more
core +1 more source
Variation in the nuclear effects of infection by different human rhinovirus serotypes.
Frontiers in Microbiology, 2015 Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localisation of host proteins.
Erin Joanne Walker +3 more
doaj +1 more source
Controlled Protein Activities with Viral Proteases, Antiviral Peptides, and Antiviral Drugs. [PDF]
ACS Chem Biol, 2023 Tague EP +4 more
europepmc +1 more source