Results 81 to 90 of about 1,219,846 (287)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Quantifying the effects of proteases on viral infections [PDF]

, 2018
In vitro experiments are necessary to understand the processes driving viral infections and to develop antivirals and vaccines. However, experiments do not completely replicate the in vivo environment, and not all cell lines used in these experiments ...
Rodriguez Garcia, Irma Thalia
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

bioRxiv, 2020
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology.
C. Muus, M. Luecken, Gökçen Eraslan, Avinash Waghray, Graham Heimberg, L. Sikkema, Yoshihiko Kobayashi, E. D. Vaishnav, Ayshwarya Subramanian, Christopher Smilie, K. Jagadeesh, Elizabeth Thu Duong, Evgenij Fiskin, E. Triglia, M. Ansari, Peiwen Cai, B. Lin, J. Buchanan, Sijia Chen, J. Shu, Adam L. Haber, Hattie Chung, Daniel T. Montoro, T. Adams, H. Aliee, J. Samuel, Allon Zaneta Andrusivova, I. Angelidis, O. Ashenberg, K. Bassler, C. Bécavin, Inbal Benhar, J. Bergenstråhle, L. Bergenstråhle, L. Bolt, Emelie Braun, L. Bui, M. Chaffin, E. Chichelnitskiy, Joshua Chiou, T. Conlon, Michael S. Cuoco, M. Deprez, David S. Fischer, A. Gillich, Joshua Gould, M. Guo, A. Gutierrez, A. C. Habermann, T. Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Alok Jaiswal, P. Jiang, Theodoros Kapellos, Christin S Kuo, L. Larsson, Michael A. Leney-Greene Kyungtae Lim, Monika Litviňuková, Ji Lu, H. Maatz, E. Madissoon, L. Mamanova, Kasidet Manakongtreecheep, C. Marquette, Ian M Mbano, A. Mcadams, Ross J. Metzger, Ahmad N. Nabhan, Sarah K Nyquist, J. Ordovas-Montañes, L. Penland, Olivier B. Poirion, S. Poli, Cancan Qi, D. Reichart, I. Rosas, J. Schupp, Rahul Sinha, R. Sit, Kamil Slowikowski, M. Slyper, N. Smith, A. Sountoulidis, M. Strunz, Dawei Sun, Carlos Talavera-López, Peng Tan, J. Tantivit, K. Travaglini, N. Tucker, K. Vernon, M. Wadsworth, J. Waldmann, Xiuting Wang, Wenjun Yan, William Zhao, Carly G. K. Ziegler   +98 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates [PDF]

, 2007
Conjugation of ubiquitin regulates multiple pathways, including the signaling cascades leading to antiviral immunity. Similarly, the ubiquitin-like peptide ISG15 mediates the antiviral response to certain viruses.
Hiscott, John, Arguello, Meztli D.
core   +1 more source

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

bioRxiv, 2020
Antiviral therapy is urgently needed to combat the coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
M. Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, L. K. Sørensen, O. Søgaard, J. Hasselstrøm, M. Winkler, Tim Hempel, L. Raich, S. Olsson, Takashi Yamazoe, Katsura Yamatsuta, H. Mizuno, S. Ludwig, F. Noé, J. Sheltzer, M. Kjolby, S. Pöhlmann   +18 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source