Results 61 to 70 of about 1,219,846 (287)
ACS Infectious Diseases, 2021 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or S2′ site(s) is associated with viral entry, which can occur at either the ...
Tiffany Tang +5 more
semanticscholar +1 more source
Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes
Current Opinion in Immunology, 2023 Host innate immune sensors are vital for the initial detection of pathogen infection. Such sensors thus need to constantly adapt in escalating evolutionary arms races with pathogens.
Lennice K. Castro, M. Daugherty
semanticscholar +1 more source
The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes [PDF]
, 2013 The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can
Ferrara, Francesca +7 more
core +1 more source
ZIKV polyprotein composition and processing by viral and host cell proteases. [PDF]
, 2023 (A) Positions of cleavage sites for host and viral proteases at the junctions between individual viral proteins are indicated by arrows. (B) NS2B-NS3pro cleavage sequences in flaviviral polyproteins. Cleavage sites in the capsid protein C and at the NS2A/
Robert C. Liddington (35197) +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Type II transmembrane serine proteases in cancer and viral infections [PDF]
, 2009 Regulated proteolysis of cellular factors is pivotal to tissue development and homeostasis, whereas uncontrolled proteolytic activity is linked to disease.
So Young Choi +8 more
core +1 more source
HeliyonInfluenza A viruses represent a significant threat to human health and animal welfare. Viral hemagglutinin cleavage by host proteases is essential for viral infectivity.
Sabrina Schleibinger +7 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The Key Role of Lysosomal Protease Cathepsins in Viral Infections
International Journal of Molecular Sciences, 2022 Cathepsins encompass a family of lysosomal proteases that mediate protein degradation and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are also found in the cytoplasm, nucleus, and extracellular space, where they are ...
Melania Scarcella +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source