Results 41 to 50 of about 1,219,846 (287)
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
eLife, 2022 Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin.
Edward R Kastenhuber +12 more
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Viral Protease Inhibitors [PDF]
, 2009 This review provides an overview of the development of viral protease inhibitors as antiviral drugs. We concentrate on HIV-1 protease inhibitors, as these have made the most significant advances in the recent past. Thus, we discuss the biochemistry of HIV-1 protease, inhibitor development, clinical use of inhibitors, and evolution of resistance.
Anderson, Jeffrey +3 more
openaire +2 more sources
Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
doaj +1 more source
Development of FRET and Stress Granule Dual-Based System to Screen for Viral 3C Protease Inhibitors
Molecules, 2023 3C proteases (3Cpros) of picornaviruses and 3C-like proteases (3CLpros) of coronaviruses and caliciviruses represent a group of structurally and functionally related viral proteases that play pleiotropic roles in supporting the viral life cycle and ...
Jingjing Zhang +6 more
doaj +1 more source
Finding proteases that make cells go viral [PDF]
Journal of Biological Chemistry, 2020 The activation of influenza virus hemagglutinin (HA) glycoprotein via cleavage by host cell proteases is essential for viral infectivity, and understanding the mechanisms for HA protein cleavage and how they may differ depending on the biological context is important for the development of flu treatments.
Hector C, Aguilar, David W, Buchholz
openaire +2 more sources
Picornaviruses and Apoptosis: Subversion of Cell Death
mBio, 2017 Infected cells can undergo apoptosis as a protective response to viral infection, thereby limiting viral infection. As viruses require a viable cell for replication, the death of the cell limits cellular functions that are required for virus replication ...
Sarah N. Croft +2 more
doaj +1 more source
A Tale of Two Proteases: MPro and TMPRSS2 as Targets for COVID-19 Therapies
Pharmaceuticals, 2023 Considering the importance of the 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in the coronavirus disease 2019 (COVID-19) pandemic, an overview of two proteases that play an important role in the infection by ...
Barbara Farkaš +3 more
doaj +1 more source
Bioinformatic Analysis of Antiviral Medicinal Compounds Against Sars Cov-2 Proteases
Kuwait Journal of Science, 2021 The world is under siege from a global pandemic caused by a novel class of coronaviruses called severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). These viruses cause severe respiratory illness leading to death.
Fahad Hassan Shah +2 more
doaj +1 more source
‘Arms Race’ Between Viral Proteases and the Host Immune System [PDF]
, 2023 Viruses with a positive-sense single-stranded RNA genome [(+)ssRNA] encode proteases that antagonize the host immune system. Examples include picornaviruses, flaviviruses, and coronaviruses. The proteases they encode cleave not only key host proteins but
Hosuru, Bindhu
core
Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent. [PDF]
PLoS ONE, 2011 Inhibitors of endosome acidification or cathepsin proteases attenuated infections mediated by envelope proteins of xenotropic murine leukemia virus-related virus (XMRV) and Ebola virus, as well as ecotropic, amphotropic, polytropic, and xenotropic murine
Haruka Kamiyama +9 more
doaj +1 more source