Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus. [PDF]
Antiviral Res, 2019 &NA; The alphaviral nonstructural protein 2 (nsP2) cysteine proteases (EC 3.4.22.‐) are essential for the proteolytic processing of the nonstructural (ns) polyprotein and are validated drug targets.
Morazzani EM +7 more
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Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism [PDF]
Pathogens, 2022 As a frontline defense mechanism against viral infections, the innate immune system is the primary target of viral antagonism. A number of virulence factors encoded by viruses play roles in circumventing host defenses and augmenting viral replication ...
Chue Vin Chin, Mohsan Saeed
doaj +2 more sources
Host proteases: key regulators in viral infection and therapeutic targeting [PDF]
Frontiers in ImmunologyViral infections pose a major threat to global health, causing severe pneumonia, meningitis, hepatitis, and fatal complications. Viruses are highly dependent on host cellular factors to complete their life cycle, and host proteases, as one of the core ...
Qiongrong Xia, Xiaohua Liu, Huacui Huang
doaj +3 more sources
A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity [PDF]
MoleculesSerine proteases are a class of enzymes that orchestrate an immune response. These proteases can be hijacked by viruses to facilitate entry and spread, while simultaneously supporting the innate immune system in neutralizing pathogens.
Alua Shagirova +4 more
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Viral proteases as targets for chemotherapeutic intervention
Current Opinion in Biotechnology, 1992 Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent ...
C. Hellen, E. Wimmer
semanticscholar +3 more sources
COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response
Frontiers in Molecular Biosciences, 2020 An acute respiratory disorder (COVID-19) that accelerated across the globe has been found to be caused by a novel strain of coronaviruses (SARS-CoV-2).
Sanchit Seth +2 more
doaj +2 more sources
Establishment of a green fluorescent protein (GFP)-based reporter for picornaviral 3C proteases [PDF]
Journal of VirologyPicornaviruses represent a diverse group of plus-stranded RNA viruses, many of which have been linked to severe diseases in both humans and animals.
Junki Hirano +8 more
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Impact of cellular proteases on the function of antiviral antibodies [PDF]
Journal of VirologyViruses evade antibodies through many mechanisms. While mutation remains the predominant pathway, host proteases can be hijacked upon viral infections and decrease antibody-mediated clearance.
Mateo Krzypow +3 more
doaj +2 more sources
Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos [PDF]
Química Nova, 2014 Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle ...
Estela Maris Freitas Muri
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Molecular mechanisms of protease precursor autoprocessing of RNA viruses: a comprehensive review [PDF]
Virology JournalMany viruses express their proteins in the form of large polyproteins comprising structural and non-structural (e.g. enzymatic) units that are released from the precursor through ordered proteolysis.
János András Mótyán +5 more
doaj +2 more sources