Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2 [PDF]
VirusesThe continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases are the most attractive targets for developing antiviral drugs.
Davide Gentile +9 more
doaj +3 more sources
In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication [PDF]
VirusesThe SARS-CoV-2 proteases Mpro and PLpro are critical targets for antiviral drug development for the treatment of COVID-19. The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins.
Cássia Delgado +11 more
doaj +2 more sources
Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors [PDF]
Viruses, 2019 Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; consequently, host proteases have been
Kyeong-Ok Chang +4 more
doaj +3 more sources
Computer-Aided Prediction of the Interactions of Viral Proteases with Antiviral Drugs: Antiviral Potential of Broad-Spectrum Drugs. [PDF]
Molecules, 2023 Human society is facing the threat of various viruses. Proteases are promising targets for the treatment of viral infections. In this study, we collected and profiled 170 protease sequences from 125 viruses that infect humans.
Ren P, Li S, Wang S, Zhang X, Bai F.
europepmc +2 more sources
Serine protease-driven entry and S2 ' cleavage flexibility of feline coronavirus during feline enterocyte infections. [PDF]
PLoS PathogensCoronaviruses not only hijack host cells to serve as viral factories but also exploit host proteolytic systems to activate their spike (S) protein, the key glycoprotein mediating receptor binding and membrane fusion.
Bixia Chen +5 more
doaj +2 more sources
Viral Proteases: Evolution of Diverse Structural Motifs to Optimize Function
Cell, 1997 Charles Craik, L M Babe
exaly +2 more sources
Viral proteases: Structure, mechanism and inhibition [PDF]
, 2022 Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV)
Schiffer, Celia A. +2 more
core +1 more source
PLoS Pathogens, 2023 The genomes of positive-sense RNA viruses encode polyproteins that are essential for mediating viral replication. These viral polyproteins must undergo proteolysis (also termed polyprotein processing) to generate functional protein units.
Danielle M Pierce +10 more
doaj +1 more source
Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza
Frontiers in Molecular Biosciences, 2021 The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2 infections, calling a need for additional therapeutic targets. The viral spike S glycoprotein binds to the human receptor angiotensin-converting enzyme 2 (ACE2) and ...
Yalda Rahbar Saadat +3 more
doaj +1 more source
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
EMBO Molecular Medicine, 2021 SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway.
Dong Wang +15 more
doaj +1 more source