Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review [PDF]
Viruses, 2021 Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored.
Abdul Wahaab +8 more
doaj +4 more sources
Recent Advances on Targeting Proteases for Antiviral Development [PDF]
VirusesViral proteases are an important target for drug development, since they can modulate vital pathways in viral replication, maturation, assembly and cell entry.
Pedro Henrique Oliveira Borges +2 more
doaj +3 more sources
Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses [PDF]
Cell Host and Microbe, 2007 Summary Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain represents a superfamily of predicted proteases found in eukaryotic,
Nadia Giannakopoulos +2 more
exaly +4 more sources
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system. [PDF]
J Exp Med, 2022 Nadkarni et al. show that human endothelial cells (EC) engage both NLRP1 and CARD8 inflammasomes. CARD8 is activated by Coxsackie B3 protease-mediated N-terminal cleavage.
Nadkarni R +14 more
europepmc +2 more sources
Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review [PDF]
VirusesViral tropism is most commonly linked to receptor use, but host cell protease use can be a notable factor in susceptibility to infection. Here we review the use of host cell proteases by human viruses, focusing on those with primarily respiratory tropism,
Bailey Lubinski, Gary R. Whittaker
doaj +4 more sources
Identification of potential plant-based inhibitor against viral proteases of SARS-CoV-2 through molecular docking, MM-PBSA binding energy calculations and molecular dynamics simulation. [PDF]
Mol Divers, 2021 The Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, SARS-CoV-2, has recently emerged as a pandemic. Here, an attempt has been made through in-silico high throughput screening to explore the antiviral compounds from traditionally ...
Gogoi B +10 more
europepmc +2 more sources
Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals. [PDF]
Front Chem, 2022 Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from
Bafna K +3 more
europepmc +2 more sources
The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration [PDF]
Communications BiologySerine proteases are important environmental contributors of enterovirus biocontrol. However, the structural features of molecular interaction accounting for the susceptibility of enteroviruses to proteases remains unexplained.
Marie-Hélène Corre +5 more
doaj +3 more sources
Viral Proteases as Targets for Coronavirus Disease 2019 Drug Development. [PDF]
J Pharmacol Exp Ther, 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to be a global threat since its emergence.
Zhu W, Shyr Z, Lo DC, Zheng W.
europepmc +2 more sources
Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19. [PDF]
J Med Virol, 2021 The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS)‐CoV, and SARS‐CoV‐2. Coronavirus disease 2019 (COVID‐19), caused by SARS‐CoV‐2,
Anirudhan V +4 more
europepmc +2 more sources