The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication [PDF]
Viruses, 2021 Various viruses alter nuclear pore complex (NPC) integrity to access the nuclear content favoring their replication. Alteration of the nuclear pore complex has been observed not only in viruses that replicate in the nucleus but also in viruses with a ...
Luis Adrián De Jesús-González +7 more
doaj +10 more sources
Plant Viral Proteases: Beyond the Role of Peptide Cutters [PDF]
Frontiers in Plant Science, 2018 Almost half of known plant viral species rely on proteolytic cleavages as key co- and post-translational modifications throughout their infection cycle. Most of these viruses encode their own endopeptidases, proteases with high substrate specificity that
Bernardo Rodamilans +3 more
doaj +11 more sources
Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune System [PDF]
Frontiers in Immunology, 2021 Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode proteases that are not ...
Brian V. Tsu +6 more
doaj +8 more sources
Diverse viral proteases activate the NLRP1 inflammasome [PDF]
eLife, 2021 The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of ...
Brian V Tsu +5 more
doaj +9 more sources
Precursors of Viral Proteases as Distinct Drug Targets [PDF]
Viruses, 2021 Viral proteases are indispensable for successful virion maturation, thus making them a prominent drug target. Their enzyme activity is tightly spatiotemporally regulated by expression in the precursor form with little or no activity, followed by ...
Taťána Majerová, Pavel Novotný
doaj +8 more sources
Viral deubiquitinating proteases and the promising strategies of their inhibition [PDF]
Virus ResearchSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling ...
Vera J.E. van Vliet +3 more
doaj +10 more sources
Viral proteases as therapeutic targets. [PDF]
Mol Aspects Med, 2022 Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and herpesviruses―code for a protease, which is indispensable for viral maturation and pathogenesis.
Majerová T, Konvalinka J.
europepmc +5 more sources
Viral proteases: Structure, mechanism and inhibition. [PDF]
Enzymes, 2021 Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV)
Zephyr J, Kurt Yilmaz N, Schiffer CA.
europepmc +5 more sources
The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases [PDF]
Molecular Aspects of Medicine, 2022 Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that respond to pathogen-associated molecular patterns (PAMPs). The recognition of specific microbial ligands by TLRs triggers an innate immune response and also promotes adaptive ...
Ewelina Dobosz +2 more
exaly +3 more sources
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach. [PDF]
J Nat Prod, 2023 In this study, an integrated in silico–in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (Mpro) and papain-like protease (PLpro), were selected as targets ...
Wasilewicz A +14 more
europepmc +2 more sources