Results 51 to 60 of about 1,219,846 (287)
Viruses, 2021 To explore the sequence context-dependent nature of the human immunodeficiency virus type 1 (HIV-1) protease’s specificity and to provide a rationale for viral mutagenesis to study the potential role of the nucleocapsid (NC) processing in HIV-1 ...
János András Mótyán +3 more
doaj +1 more source
Tomato marchitez virus, a new plant picorna-like virus from tomato related to tomato torrado virus [PDF]
, 2008 A new virus was isolated from a tomato plant from the state of Sinaloa in Mexico. This plant showed symptoms locally known as `marchitez disease¿: severe leaf necrosis, beginning at the base of the leaflets, and necrotic rings on the fruits.
Verbeek, M. +4 more
core +1 more source
IUCrJ, 2014 For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution.
Nuria Verdaguer +2 more
doaj +1 more source
Coagulation, Protease-Activated Receptors, and Viral Myocarditis [PDF]
Journal of Cardiovascular Translational Research, 2013 The coagulation protease cascade plays an essential role in hemostasis. In addition, a clot contributes to host defense by limiting the spread of pathogens. Coagulation proteases induce intracellular signaling by cleavage of cell surface receptors called protease-activated receptors (PARs).
Silvio, Antoniak, Nigel, Mackman
openaire +2 more sources
Virology Journal, 2009 Avian influenza viruses continue to threaten globally with pandemic potential. The first step in a potential pandemic is the ability of the virus to enter human cells which is mediated by the viral surface glycoprotein hemagglutinin (HA).
Caffrey Michael +4 more
doaj +1 more source
Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.) [PDF]
, 2022 SARS-CoV-2 is a highly transmissible and pathogenic coronavirus causing a respiratory disease that emerged in 2019, leading to a public health emergency situation which continues to date.
María Ángeles Ávila-Gálvez , Carlos Rafael-Pita, Naiara Fernández, João Baixinho, José D. Anastácio, Katarina Cankar, Dirk Bosch, and Cláudia Nunes dos Santos
core +1 more source
EBioMedicine, 2021 Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However,
M. Hoffmann +22 more
semanticscholar +1 more source
The role of proteases in the invasion of SARS-CoV-2 virus into human host cells
Journal of Current Biomedical Reports, 2021 The new coronavirus, which originally broke out in Wuhan, China, in December 2019, increase quickly around the world, causing a pandemic all over the world. The virus uses its spike protein to enter the human host cells.
Maryam Saeidi, Fatemeh Rouhollah
doaj +1 more source
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
Frontiers in Chemistry, 2022 The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the third occurrence of a highly pathogenic coronavirus in the human population since 2003.
Z. Lv +5 more
semanticscholar +1 more source
Nature Communications, 2021 During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al.
Bjoern Meyer +18 more
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