Results 251 to 260 of about 1,218,197 (305)

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Large language models improve annotation of prokaryotic viral proteins. [PDF]

Nat Microbiol
Flamholz ZN, Biller SJ, Kelly L.
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1. [PDF]

Autophagy
Zhang MQ, Li JR, Yang L, Peng ZG, Wu S, Zhang JP.   +5 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication. [PDF]

Front Cell Infect Microbiol
Ma-Lauer Y, Li P, Niemeyer D, Richter A, Pusl K, von Brunn B, Ru Y, Xiang C, Schwinghammer S, Liu J, Baral P, Berthold EJ, Qiu H, Roy A, Kremmer E, Flaswinkel H, Drosten C, Jin Z, von Brunn A.   +18 more
europepmc   +1 more source

Viral proteins resolve the virus-vector conundrum during hemipteran-mediated transmission by subverting salicylic acid signaling pathway. [PDF]

Nat Commun
Zhang JR, Liu YM, Li D, Wu YJ, Zhao SX, Wang XW, Liu SS, Walling LL, Pan LL.   +8 more
europepmc   +1 more source

SMILES-based QSAR virtual screening to identify potential therapeutics for COVID-19 by targeting 3CL^pro and RdRp viral proteins. [PDF]

BMC Chem
Bazzi-Allahri F, Shiri F, Ahmadi S, Toropova AP, Toropov AA.   +4 more
europepmc   +1 more source

Correction: Performance assessment of a new serological diagnostic test for COVID-19 with candidate peptides from spike and nucleocapsid viral proteins. [PDF]

Braz J Microbiol
Cavalcanti-Dantas VM, da Silva AF, Mendes AF, de Araújo Júnior WO, Bernardo-Menezes LC, Bresani-Salvi CC, Castellano LRC, Fernandes AIV, Lemos SG, de Magalhães JJF, Oliveira RADS, de Assis PAC, de Souza JR, de Morais CNL.   +13 more
europepmc   +1 more source

Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections. [PDF]

Biochim Biophys Acta Mol Cell Res
Maio N, Heffner AL, Rouault TA.
europepmc   +1 more source