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Viral complement regulatory proteins
Immunopharmacology, 1999The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins.
A M, Rosengard, J M, Ahearn
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Viral chemokine-binding proteins
Journal of Leukocyte Biology, 2002AbstractThe chemokines are a large family of small signaling proteins that bind to G-protein-coupled receptors (GPCRs) on target cells and mediate the directional migration of immune cells into sites of infection or inflammation. The large DNA viruses, particularly the poxviruses and herpesviruses, have evolved several mechanisms to corrupt the normal ...
Bruce T, Seet, Grant, McFadden
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Identification of Immunoreactive Viral Proteins
2003Several diagnostic tools are available for the identification of acute and latent viral infections. Although newly developed nucleic acid amplification methods, such as the polymerase chain reaction (PCR), have proved to be very useful diagnostic procedures, conventional methods, such as cell culture and serology, still play an important role in viral ...
W, Hinderer, B, Plachter, R, Vornhagen
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Synthesis of Tacaribe viral proteins
Virology, 1979Abstract The synthesis of Tacaribe virus-specific proteins in infected BHK-21 cells has been analyzed by polyacrylamide slab gel electrophoresis and fluorography. The two major structural polypeptides of the virion were observed above the host cell background by pulse labeling with amino acid or sugar precursors.
F, Saleh, G P, Gard, R W, Compans
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Viral protein kinases and protein phosphatases
Pharmacology & Therapeutics, 1993Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth
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Myristoylation of viral and bacterial proteins
Trends in Microbiology, 2004Abstract Myristoylation, the N-terminal attachment of a myristoyl lipid anchor to a glycine residue, can reversibly direct protein–membrane and protein–protein interactions. Apart from two entomopoxviruses, viruses and bacteria usually lack the enzyme N-myristoyltransferase (NMT) that is required for this modification, and their proteins are ...
Sebastian, Maurer-Stroh +1 more
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1995
Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Intercellular Transport of Viral Proteins
Viruses are vehicles to exchange genetic information and proteins between cells and organisms by infecting their target cells either cell-free, or depending on cell-cell contacts. Several viruses like certain retroviruses or herpesviruses transmit by both mechanisms.Florian, Simon, Andrea K, Thoma-Kress
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Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins
Current Gene Therapy, 2011The transient delivery of gene products (RNA or proteins) is not a biotechnological invention but rather an evolutionarily conserved process underlying and regulating a variety of biological functions. On the basis of insights into the underlying mechanisms, several viral and cell-based approaches have been developed for the delivery of RNA or proteins.
Juliane W, Schott +4 more
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The Viral Tyrosine Protein Kinases
1986The acutely transforming retroviruses have revealed the existence of more than twenty different genes with oncogenic potential. Seven of these — src, abl, yes, erbB, fps (fes), fgr, fms, and ros — encode proteins with intrinsic tyrosine protein kinase activity.
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