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Relationship between viral RNA and viral protein synthesis
Virology, 1962Abstract Low concentrations of p-fluorophenylalanine (5–10 μg/ml) inhibit the maturation of Western equine encephalomyelitis and poliomyelitis viruses. Much higher concentrations are required (125 μg/ml) to inhibit the synthesis of the respective infectious RNA. By means of fluorescent antibodies against poliovirus, it was found that the formation of
E, WECKER, K, HUMMELER, O, GOETZ
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Modulation of mitochondria by viral proteins
Life Sciences, 2023Mitochondria are dynamic cellular organelles with diverse functions including energy production, calcium homeostasis, apoptosis, host innate immune signaling, and disease progression. Several viral proteins specifically target mitochondria to subvert host defense as mitochondria stand out as the most suitable target for the invading viruses.
Reshu, Saxena +5 more
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Viral complement regulatory proteins
Immunopharmacology, 1999The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins.
A M, Rosengard, J M, Ahearn
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Myristoylation of viral and bacterial proteins
Trends in Microbiology, 2004Abstract Myristoylation, the N-terminal attachment of a myristoyl lipid anchor to a glycine residue, can reversibly direct protein–membrane and protein–protein interactions. Apart from two entomopoxviruses, viruses and bacteria usually lack the enzyme N-myristoyltransferase (NMT) that is required for this modification, and their proteins are ...
Sebastian, Maurer-Stroh +1 more
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Identification of Immunoreactive Viral Proteins
2003Several diagnostic tools are available for the identification of acute and latent viral infections. Although newly developed nucleic acid amplification methods, such as the polymerase chain reaction (PCR), have proved to be very useful diagnostic procedures, conventional methods, such as cell culture and serology, still play an important role in viral ...
W, Hinderer, B, Plachter, R, Vornhagen
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Viral protein kinases and protein phosphatases
Pharmacology & Therapeutics, 1993Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth
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Viral chemokine-binding proteins
Journal of Leukocyte Biology, 2002AbstractThe chemokines are a large family of small signaling proteins that bind to G-protein-coupled receptors (GPCRs) on target cells and mediate the directional migration of immune cells into sites of infection or inflammation. The large DNA viruses, particularly the poxviruses and herpesviruses, have evolved several mechanisms to corrupt the normal ...
Bruce T, Seet, Grant, McFadden
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1995
Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Since the discovery of the human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2) as the causative agents of acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al. 1983; Clavel et al. 1987; Papovic et al. 1984) and the isolation of related lentiviruses from several species of Old World monkeys, much has been learned about their biology ...
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Trafficking of Viral Membrane Proteins
2005Many viruses express membrane proteins. For enveloped viruses in particular, membrane proteins are frequently structural components of the virus that mediate the essential tasks of receptor recognition and membrane fusion. The functional activities of these proteins require that they are sorted correctly in infected cells.
R, Byland, M, Marsh
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